Cellular models as tools for the study of the role of alpha-synuclein in Parkinson's disease

Experimental Neurology
Diana F LázaroTiago Fleming Outeiro

Abstract

Neurodegenerative diseases are highly debilitating conditions characterised primarily by progressive neuronal loss and impairment of the nervous system. Parkinson's disease (PD) is one of the most common of these disorders, affecting 1-2% of the population above the age of 65. Although the underlying mechanisms of PD have been extensively studied, we still lack a full understanding of the molecular underpinnings of the disease. Thus, the in vitro and in vivo models currently used are able to only partially recapitulate the typical phenotypes of the disease. Here, we review various cell culture models currently used to study the molecular basis of PD, with a focus on alpha-synuclein-associated molecular pathologies. We also discuss how different cell models may constitute powerful tools for high-throughput screening of molecules capable of modulating alpha-synuclein toxicity.

Citations

Apr 21, 2019·Journal of Neurochemistry·Amir Tayaranian MarvianTiago Fleming Outeiro
Jul 3, 2019·Journal of Neurochemistry·Marion DelenclosPamela J McLean
Apr 8, 2020·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Hugo Vicente MirandaTiago Fleming Outeiro
Jan 21, 2020·Journal of Neurochemistry·Inês Caldeira BrásTiago Fleming Outeiro
Jul 30, 2020·The Neuroscientist : a Review Journal Bringing Neurobiology, Neurology and Psychiatry·Anuradha YadavRajnish Kumar Chaturvedi
Jan 25, 2018·Expert Opinion on Drug Discovery·Ines Trigo-DamasJavier Blesa
Jan 9, 2019·Frontiers in Neuroanatomy·Natalia López-González Del ReyJavier Blesa
Apr 4, 2019·Frontiers in Pharmacology·Hayate JavedShreesh Kumar Ojha
Jun 13, 2020·Frontiers in Cell and Developmental Biology·Anna SlanziGabriela Constantin
Mar 7, 2021·International Journal of Molecular Sciences·Marco GrecoMichele Maffia
Apr 18, 2021·Journal of Integrative Medicine·Reem Abdul-LatifThilini Thrimawithana
Oct 10, 2021·Nature Communications·Iosif PediaditakisKatia Karalis
Oct 23, 2020·Pharmacology, Biochemistry, and Behavior·Tanvi Pingale, Girdhari Lal Gupta

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Alpha-Synuclein Aggregation (MDS)

Alpha-synucleins are small proteins that are believed to restrict the mobility of synpatic vesicles and inhibit neurotransmitter release. Aggregation of these proteins have been linked to several types of neurodegenerative diseases including dementia with Lewy bodies and Parkinson's disease. Here is the latest research on α-synuclein aggregation.

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