Abstract
Cellular neurothekeoma (CNT) is a benign dermal tumor mainly affecting the head and neck and the upper extremities. It is characterized histologically by interconnecting fascicles of plump spindle or epithelioid cells with ample cytoplasm infiltrating in the reticular dermis. The histogenesis of CNT has been controversial, although it is generally regarded as an immature counterpart of classic/myxoid neurothekeoma, a tumor with nerve sheath differentiation. Two rare cases of CNT containing melanin-laden cells were described. Immunohistochemical study with NKI/C3, vimentin, epithelial membrane antigen, smooth muscle antigen, CD34, factor XIIIa, collagen type IV, S100 protein and HMB-45 was performed. Both cases showed typical growth pattern of CNT with interconnecting fascicles of epithelioid cells infiltrating in collagenous stroma. One of the nodules contained areas exhibiting atypical cytological features. Melanin-laden epithelioid or dendritic cells were diffusely scattered throughout one nodule, and focally present in the peripheral portion of the other nodule. Both nodules were strongly immunoreactive to NKI/C3 and vimentin, but negative to all the other markers employed. CNT harboring melanin-laden cells may pose diagnost...Continue Reading
References
May 1, 1992·Histopathology·E CalonjeC D Fletcher
Jul 11, 1991·Journal of the American Academy of Dermatology·R L BarnhillM C Mihm
Feb 1, 1990·The American Journal of Surgical Pathology·R L Barnhill, M C Mihm
Jun 1, 1989·Journal of Cutaneous Pathology·M AkiyamaT Nishikawa
Oct 1, 1994·The American Journal of Dermatopathology·S HusainN S McNutt
Apr 1, 1995·Journal of Cutaneous Pathology·Z B ArgenyiM M Seaba
Aug 1, 1993·Journal of Cutaneous Pathology·Z B ArgenyiH Kutzner
Jun 25, 1998·Histopathology·B G ZelgerB Zelger
Sep 16, 1998·The American Journal of Surgical Pathology·K J BusamC D Fletcher
Feb 23, 1999·The American Journal of Dermatopathology·N MisagoN Yonemitsu
Nov 11, 1999·The American Journal of Surgical Pathology·A R WangG Scott
Nov 9, 2000·Human Pathology·W B LaskinM Miettinen
Jan 23, 2002·The American Journal of Dermatopathology·Pierre Rudolph, Christoph Schubert
Mar 19, 2003·Journal of Cutaneous Pathology·Douglas R FullenLyndon D Su
Dec 20, 2003·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Robert N PagePaul B Googe
Jul 23, 2004·Journal of Cutaneous Pathology·Noriyuki MisagoYutaka Narisawa
Sep 11, 2004·Development·Nicole M Le DouarinElisabeth Dupin