PMID: 8594913Dec 1, 1995Paper

Cellular pathways of the conducted electrical response in arterioles of hamster cheek pouch in vitro

The American Journal of Physiology
J XiaB R Duling

Abstract

We have previously shown that conducted vasomotor responses follow patterns that are consistent with a passive spread of electrical current along the length of the arterioles [(Xia and Duling, Am. J. Physiol. 269 (Heart Circ. Physiol. 38): H2022-H2030, 1995]. In this study, we define the cells through which the current flows. Isolated arterioles of hamster cheek pouch were used. The mean resting membrane potential (RMP) for randomly sampled arteriolar cells was -67 mV. When cell types were identified by dye injection, the RMPs were -68 and -67 mV for smooth muscle (SM) and endothelium (EC), respectively. Pulses of KCl induced transient, monophasic depolarizations at the site of stimulation (local), which were conducted decrementally along the length of the arteriole over several millimeters. During electrical conduction, three patterns of responses could be observed, but identical patterns of the conducted electrical responses were always observed in SM and EC. Phenylephrine stimulation also caused transient local and conducted depolarizations in both SM and EC. As with KCl stimuli, shapes of conducted electrical responses were identical in records made in both cell types. The results suggest that SM and EC are electrically cou...Continue Reading

Citations

Jul 19, 2000·American Journal of Physiology. Heart and Circulatory Physiology·K A DoraB R Duling
Jun 14, 2000·American Journal of Physiology. Heart and Circulatory Physiology·K D CohenI H Sarelius
Sep 24, 2004·Physiology·Xavier F FigueroaBrian R Duling
Dec 5, 2006·Current Opinion in Nephrology and Hypertension·William A Cupples
Mar 17, 2007·The Journal of Physiology·Marika L ArmstrongCoral L Murrant
Jan 28, 2009·The Journal of Physiology·Cam Ha T TranDonald G Welsh
Nov 4, 2016·Microcirculation : the Official Journal of the Microcirculatory Society, Inc·Nadia MaaroufDonald G Welsh
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Oct 25, 2000·American Journal of Physiology. Heart and Circulatory Physiology·C L Murrant, I H Sarelius
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Jun 8, 2001·News in Physiological Sciences : an International Journal of Physiology Produced Jointly by the International Union of Physiological Sciences and the American Physiological Society·Jean-Louis Bény
Jun 10, 2003·American Journal of Physiology. Heart and Circulatory Physiology·Kim A DoraBrian R Duling
Nov 14, 2006·American Journal of Physiology. Heart and Circulatory Physiology·Torben R UhrenholtSteven S Segal
Jun 8, 2018·International Journal of Molecular Sciences·Filippo MolicaJonathan M Gibbins
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