Cellular plasticity: the good, the bad, and the ugly? Microenvironmental influences on progenitor cell therapy

Canadian Journal of Physiology and Pharmacology
Jan-Renier A J MoonenGuido Krenning

Abstract

Progenitor cell based therapies have emerged for the treatment of ischemic cardiovascular diseases where there is insufficient endogenous repair. However, clinical success has been limited, which challenges the original premise that transplanted progenitor cells would orchestrate repair. In this review, we discuss the basics of endothelial progenitor cell therapy and describe how microenvironmental changes (i.e., trophic and mechano-structural factors) in the damaged myocardium influence progenitor cell plasticity and hamper beneficial therapeutic outcome. Further understanding of these microenvironmental clues will enable optimization of cell therapy at all levels. We discuss current concepts and provide future perspectives for the enhancement of progenitor cell therapy, and merge these advances into a combined approach for ischemic tissue repair.

References

May 1, 1985·Arteriosclerosis : an Official Journal of the American Heart Association, Inc·D N KuS Glagov
Nov 1, 1995·Calcified Tissue International·R L Duncan, C H Turner
Jan 1, 1997·Annual Review of Physiology·D E Ingber
Apr 21, 1997·The Journal of Cell Biology·R L KlemkeD A Cheresh
Feb 12, 1998·Proceedings of the National Academy of Sciences of the United States of America·R J Pelham, Y l Wang
May 23, 1998·Arteriosclerosis, Thrombosis, and Vascular Biology·O Traub, B C Berk
Jan 21, 2003·Laboratory Investigation; a Journal of Technical Methods and Pathology·Takako AkitaTsutomu Imaizumi
Apr 8, 2004·Developmental Cell·Rowena McBeathChristopher S Chen
Oct 16, 2004·Biotechnology and Bioengineering·Jennifer S ParkSong Li
Dec 4, 2004·American Journal of Physiology. Heart and Circulatory Physiology·Kimiko YamamotoJoji Ando
Feb 8, 2005·Inflammation Research : Official Journal of the European Histamine Research Society ... [et Al.]·N G Frangogiannis
Jul 5, 2005·Journal of Molecular and Cellular Cardiology·S VanderveldeM C Harmsen
Aug 3, 2005·The Journal of Clinical Investigation·Ichiro ShiojimaKenneth Walsh
Oct 22, 2005·Circulation Research·Marta SauraManuel Rodriguez-Puyol
Nov 16, 2005·Journal of the American College of Cardiology·Thomas ThumStefan D Anker
Dec 3, 2005·Arteriosclerosis, Thrombosis, and Vascular Biology·Nikos Werner, Georg Nickenig
Feb 14, 2006·American Journal of Physiology. Heart and Circulatory Physiology·Mark F BerryH Lee Sweeney
Mar 15, 2006·Cardiovascular Pathology : the Official Journal of the Society for Cardiovascular Pathology·Susanne VanderveldeMartin C Harmsen
Jun 20, 2006·Journal of Molecular and Cellular Cardiology·Eliane R PopaMarja J A van Luyn
Aug 23, 2006·Cell·Adam J EnglerDennis E Discher
Nov 28, 2006·Frontiers in Bioscience : a Journal and Virtual Library·Thomas J Burkholder
Dec 13, 2006·Journal of the American College of Cardiology·Pawel ZymekNikolaos G Frangogiannis
Jan 9, 2007·Cardiovascular Research·Susanne VanderveldeMartin C Harmsen
Feb 27, 2007·The American Journal of Pathology·Machteld J van AmerongenMarja J A van Luyn
May 11, 2007·Journal of Molecular and Cellular Cardiology·B W A van der StrateM J A van Luyn
May 15, 2007·Circulation Research·Jeffrey M GimbleBruce A Bunnell
Sep 4, 2007·Arthritis Research & Therapy·Jan Renier A J MoonenMartin C Harmsen

❮ Previous
Next ❯

Citations

Feb 24, 2016·Stem Cells International·Guido KrenningJan-Renier A J Moonen

❮ Previous
Next ❯

Related Concepts

Related Feeds

Adult Stem Cells

Adult stem cells reside in unique niches that provide vital cues for their survival, self-renewal, and differentiation. They hold great promise for use in tissue repair and regeneration as a novel therapeutic strategies. Here is the latest research.