Cellular prion protein regulates invasion and migration of breast cancer cells through MMP-9 activity

Biochemical and Biophysical Research Communications
Minchan GilKyung Jin Lee

Abstract

Function of cellular prion protein (PrP(c)) in cancer progression has not been elucidated yet. Ectopic expression of PrP(c) increases the invasion and migration of breast cancer cell line, MCF-7 cells. Overexpressed PrP(c) increases matrix metalloprotease-9 (MMP-9) expression by enhancing association of NF-κB in promoter of MMP-9 gene and ERK signaling in MCF-7 cells. Whereas, silencing of PrP(c) by siRNA suppresses ERK activation and MMP-9 expression resulting the down-regulation of MD-MB231 cell migration and invasion. Overall, these results suggest that PrP(c) contribute the breast cancer invasion and migration via MMP-9.

References

Jan 21, 2000·Free Radical Biology & Medicine·H SauerM Wartenberg
Nov 5, 2003·Proceedings of the National Academy of Sciences of the United States of America·Benoît SchneiderOdile Kellermann
Sep 24, 2004·International Journal of Cancer. Journal International Du Cancer·Jingping DuDaiming Fan
Jan 3, 2006·Cardiovascular Research·Joost P G SluijterGerard Pasterkamp
May 9, 2006·Cancer Metastasis Reviews·Elena I Deryugina, James P Quigley
Aug 1, 2006·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Yanglin PanDaiming Fan
Jul 20, 2007·Journal of Cell Science·Kyung-Jin LeeEvan Eisenberg
Feb 1, 2008·Annual Review of Pathology·Adriano AguzziMathias Heikenwaelder
Aug 14, 2009·Cancer Letters·Maryam Mehrpour, Patrice Codogno
Aug 18, 2009·Biochimica Et Biophysica Acta·Thomas R Geiger, Daniel S Peeper
Sep 10, 2009·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Roopali RoyMarsha A Moses
Dec 7, 2010·Trends in Biochemical Sciences·Claudio Soto
Dec 8, 2011·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·Vincenzo SollazzoFrancesco Carinci
Mar 19, 2013·Breast Cancer Research : BCR·Marc-André DéryAndréa C LeBlanc
Jan 30, 2014·Cancers·Antonietta Rosella Farina, Andrew Reay Mackay
Sep 15, 2014·Acta histochemica·Jenifer BottinoDebora Aparecida Pires de Campos Zuccari
Sep 22, 2015·Frontiers in Immunology·Maren K BakkebøMichael A Tranulis

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Citations

Jul 6, 2017·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Ahmet ÖzdemirFatih Demirci
Jul 25, 2018·Critical Reviews in Biochemistry and Molecular Biology·Stéphanie LebretonSimona Paladino
Sep 17, 2020·International Journal of Molecular Sciences·Mariana Brandão PradoMarilene Hohmuth Lopes
Apr 26, 2021·Journal of Oral Pathology & Medicine : Official Publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology·Eloa Mangabeira SantosAndré Luiz Sena Guimarães

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