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Cellular processing of platinum anticancer drugs

Nature Reviews. Drug Discovery

Apr 1, 2005

Dong Wang, Stephen J. Lippard

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Abstract

Cisplatin, carboplatin and oxaliplatin are platinum-based drugs that are widely used in cancer chemotherapy. Platinum-DNA adducts, which are formed following uptake of the drug into the nucleus of cells, activate several cellular processes that mediate the cytotoxicity of these platinum...read more

Mentioned in this Paper

Apoptosis, Intrinsic Pathway
Antineoplastic Agents
Tumor Cells, Cultured
Cell Death
Oxaliplatin
DNA Damage
DNA Adducts
Cell Nucleus
Biochemical Pathway
Organoplatinum Compounds
980
1
Paper Details
References
  • References185
  • Citations1013
12345...

Cellular processing of platinum anticancer drugs

Nature Reviews. Drug Discovery

Apr 1, 2005

Dong Wang, Stephen J. Lippard

PMID: 15789122

DOI: 10.1038/nrd1691

Abstract

Cisplatin, carboplatin and oxaliplatin are platinum-based drugs that are widely used in cancer chemotherapy. Platinum-DNA adducts, which are formed following uptake of the drug into the nucleus of cells, activate several cellular processes that mediate the cytotoxicity of these platinum...read more

Mentioned in this Paper

Apoptosis, Intrinsic Pathway
Antineoplastic Agents
Tumor Cells, Cultured
Cell Death
Oxaliplatin
980
1
Paper Details
References
  • References185
  • Citations1013
12345...

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