PMID: 8603699Feb 5, 1996Paper

Cellular processing of the neurotrophin precursors of NT3 and BDNF by the mammalian proprotein convertases

FEBS Letters
N G SeidahR A Murphy

Abstract

In order to define the enzymes responsible for the maturation of the precursors of brain-derived neurotrophic factor (proBDNF) and neurotrophin-3 (proNT3), we have analysed their biosynthesis and intracellular processing by the proprotein convertases furin, PC1, PC2, PACE4, PC5 and its isoform PC5/6-B. In these studies, we utilized a vaccinia virus expression system in either BSC40 or the furin activity-deficient LoVo cells. Results demonstrated that in both cells furin and, to a lesser extent, PACE4 and PC5/6-B effectively process proBDNF and proNT3. Furthermore, we have determined that human proNT3 is sulfated, suggesting that processing of proNT3 occurs following the arrival of the precursor to the Trans Golgi Network.

References

Mar 23, 1990·Science·P C MaisonpierreG D Yancopoulos
Sep 4, 1987·Science·R Levi-Montalcini
Sep 15, 1993·Biochemical and Biophysical Research Communications·S TakahashiK Nakayama
Jan 1, 1994·Methods in Enzymology·N G Seidah, M Chrétien
Aug 19, 1994·Science·R Nishi

❮ Previous
Next ❯

Citations

Mar 22, 2014·Biomedical Reports·Ai ChenMeng Mao
Sep 5, 2013·Journal of Korean Neurosurgical Society·Bit-Na-Ri ParkSung-Hoon Kim
Jul 2, 2019·Journal of Neuroscience Research·Hanna KletkiewiczJustyna Rogalska
Mar 26, 2014·Clinical Journal of Sport Medicine : Official Journal of the Canadian Academy of Sport Medicine·Arsalan DamirchiParvin Babaei
Nov 6, 2018·The Neuroscientist : a Review Journal Bringing Neurobiology, Neurology and Psychiatry·Michael Notaras, Maarten van den Buuse
Jan 22, 2001·The Journal of Biological Chemistry·S J MowlaR A Murphy
Jul 3, 2020·Journal of Nutritional Science and Vitaminology·Kensuke NakajimaHiroko Kariyazono
Jan 14, 2000·Developmental Dynamics : an Official Publication of the American Association of Anatomists·T AkamatsuK Hosoi
Sep 9, 2020·Cell and Tissue Research·Masami KojimaTeiichi Furuichi
Feb 27, 2004·The European Journal of Neuroscience·A Del SignoreP Paggi
Aug 3, 2005·Nature Reviews. Neuroscience·Bai LuNewton H Woo
May 25, 2006·European Journal of Human Genetics : EJHG·Nick Craddock, Liz Forty
Feb 27, 2008·The Journal of Biological Chemistry·Jacqueline BoutilierPhilip A Barker
May 15, 2008·Journal of Neural Transmission·Martin MarziniakClaudia Sommer
Aug 22, 2009·Expert Opinion on Therapeutic Targets·Michelle K Y SiuAnnie N Y Cheung
Feb 20, 2010·Annals of Medicine·Yogesh Dwivedi
Oct 13, 2010·Molecular Psychiatry·T Nickl-Jockschat, T M Michel
Sep 9, 2011·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Dong Hyun KimJong Hoon Ryu
Jul 9, 2013·Journal of Neuroimmune Pharmacology : the Official Journal of the Society on NeuroImmune Pharmacology·Italo MocchettiValeriya Avdoshina
Oct 9, 2013·Proceedings of the National Academy of Sciences of the United States of America·William C WetselNabil G Seidah
Jan 14, 2017·Molecular Neurobiology·Yoon LimXin-Fu Zhou
Jul 15, 2017·Journal of Neuroengineering and Rehabilitation·R D Seidler, R G Carson
Mar 27, 2018·Developmental Neurobiology·Wei GuoBai Lu
May 29, 2018·Psychiatry and Clinical Neurosciences·Juzoh UmemoriEero Castrén
May 1, 2020·Frontiers in Cellular Neuroscience·Tao YangHuiying Liu
Jan 31, 2004·The European Journal of Neuroscience·Patrick KüryHans Werner Müller
Feb 25, 2003·Annual Review of Neuroscience·Rosalind A Segal
Jan 4, 2006·American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics : the Official Publication of the International Society of Psychiatric Genetics·Araceli RosaLourdes Fañanás
Jul 19, 2005·Nature Neuroscience·Newton H WooBai Lu
Jan 8, 2009·Physiological Reviews·Andrea Caporali, Costanza Emanueli
Jan 17, 2009·Proceedings of the National Academy of Sciences of the United States of America·Guhan NagappanBai Lu

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.