Cellular proliferation and angiogenesis in nasal polyps of young adult and geriatric patients

International Forum of Allergy & Rhinology
Jae Min ShinJae Yong Lee

Abstract

Cellular proliferation and angiogenesis are associated with pathophysiology of nasal polyposis (NP). In a previous report, we showed that patient age is a predictive factor of surgical outcomes among patients with chronic rhinosinusitis and NP, and that geriatric patients exhibit better outcomes than pediatric and adult patients. We postulated that better outcomes in the geriatric population may be secondary to decreased proliferation and angiogenesis within polyps. Therefore, we evaluated the cellular proliferation and angiogenesis in young adult and geriatric patients with NP. This was a prospective case-control study. Twenty patients were divided into 2 groups according to age (20 to 30 years vs ≥65 years of age). NP tissues were sampled during endoscopic sinus surgery and processed for immunohistochemistry. Cellular proliferation was evaluated with proliferating cell nuclear antigen and Ki67, and angiogenesis was assessed with vascular endothelial growth factor. We also compared objective surgical outcomes using endoscopy scores. Immunohistochemical analysis revealed significantly higher expression and positive reactivity of proliferating cell nuclear antigen and Ki67 in the polyps of young adults than in those of geriatric...Continue Reading

References

Apr 1, 1996·Archives of Otolaryngology--head & Neck Surgery·A CosteE Escudier
Jan 23, 1999·The Laryngoscope·H H Ramadan
Dec 29, 2000·The Annals of Otology, Rhinology, and Laryngology·R S Jiang, C Y Hsu
Jul 13, 2002·European Archives of Oto-rhino-laryngology : Official Journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : Affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery·Claus WittekindtOlaf Michel
Oct 12, 2002·American Journal of Physiology. Lung Cellular and Molecular Physiology·William M ManiscalcoColleen P Shea
May 6, 2004·The Laryngoscope·Rhoda Wynn, Gady Har-El
Oct 29, 2004·The Laryngoscope·R Tyson Deal, Stilianos E Kountakis
Dec 6, 2005·Otolaryngologic Clinics of North America·Joel M Bernstein
Aug 30, 2008·Therapeutics and Clinical Risk Management·Jonathan Ray Newton, Kim Wong Ah-See
Mar 8, 2012·Molecular Medicine Reports·Alexandros D KaratzanisNikolaos M Siafakas
Jan 16, 2014·Indian Journal of Otolaryngology and Head and Neck Surgery : Official Publication of the Association of Otolaryngologists of India·Ilter TezerSedat Aydin

❮ Previous
Next ❯

Citations

Jul 28, 2016·American Journal of Rhinology & Allergy·Charles A Riley, Ronald G Amedee
Sep 24, 2016·American Journal of Rhinology & Allergy·Giuseppe BresciaGino Marioni

❮ Previous
Next ❯

Related Concepts

Related Feeds

Arterial-Venous in Development & Disease

Arterial-venous development may play a crucial role in cardiovascular diseases. Here is the latest research.