Cellular quiescence: How TGFβ protects cancer cells from chemotherapy

Molecular & Cellular Oncology
Jessie A Brown, Markus Schober

Abstract

Using a functional proliferation reporter we identified quiescent tumor propagating cancer cells (TPCs) in intact squamous cell carcinomas, and found that TGFβ signaling controls their reversible entry into a growth arrested state, which protects TPCs from chemotherapy. TPCs with compromised TGFβ/Smad signaling can't enter quiescence and subsequently die from chemotherapy.

References

Sep 27, 2000·Proceedings of the National Academy of Sciences of the United States of America·H TaniP Kaur
May 2, 2003·Nature Reviews. Cancer·Daniel B LongleyPatrick G Johnston
Dec 13, 2003·Science·Tudorita TumbarElaine Fuchs
Jun 15, 2011·Proceedings of the National Academy of Sciences of the United States of America·Markus Schober, Elaine Fuchs
Jan 30, 2015·Nature·UNKNOWN Cancer Genome Atlas Network
May 12, 2016·Cancer Cell·G Paolo Dotto, Anil K Rustgi

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