PMID: 8958777Nov 1, 1996Paper

Cellular receptors for sex steroids in human pituitary adenomas

The Journal of Endocrinology
M L Jaffrain-ReaA Gulino

Abstract

Cellular receptors for sex steroids (SSRs) were studied in an unselected series of 55 human pituitary tumors. Cytosolic receptors for estrogen (ERcs) and progesterone (PgRcs) were determined in all cases and cytosolic androgen receptors (ARcs) in 47 cases. Nuclear receptors (ERns, PgRns, ARns) were also studied in 33 cases. ERs and PgRs were determined by an ELISA and ARs by [3H]methyltrienolone binding. Where both cytosolic and nuclear receptors were studied (n = 33), ERs, PgRs and ARs were found in at least one subcellular fraction in 66.7, 60.6 and 81.8% of cases respectively, ERs and ARs being mainly recovered from the cytosol and PgRs from the nucleus. No linear correlation was found between pre-operative plasma steroid hormones and their specific cellular receptors. Nonetheless, the differential expression of SSRs according to sex and gonadal status at the time of surgery strongly supports their regulation by the steroid environment in vivo: PgRcs were more frequent in tumors found in women (41.4 vs 15.4%, P < 0.05), whereas a high expression of ERcs and ARcs (> 15 fmol/mg protein) was more common in tumors found in men (34.5 vs 10.3%, P < 0.05 and 54.5 vs 24.0% respectively). PgRs were positively correlated with ERns, in...Continue Reading

Citations

Jan 30, 2008·Endocrine Pathology·Bernd W ScheithauerJeffrey Slezak
May 24, 2003·Frontiers in Neuroendocrinology·Andy Levy, Stafford Lightman
Jan 24, 2002·The Journal of Clinical Investigation·Anthony P HeaneyShlomo Melmed
Oct 4, 2013·European Journal of Endocrinology·Etienne DelgrangeDominique Maiter
Mar 13, 2014·Reproductive Biology·Laura D RatnerIlpo T Huhtaniemi
Aug 25, 2012·European Journal of Endocrinology·Laurent VroonenAlbert Beckers
Sep 1, 1999·Clinical Endocrinology·M L Jaffrain-ReaS Martinotti
Feb 24, 2001·Pathology, Research and Practice·W SaegerD K Lüdecke
Nov 23, 2011·Clinical Neurology and Neurosurgery·Chao WangJun-sheng Wang
Aug 5, 2016·Cancer Research and Treatment : Official Journal of Korean Cancer Association·Jinxiang HuangXuehua Ding
Jan 9, 2019·Pathology Oncology Research : POR·Tamás DeliAttila Jakab
Mar 29, 2014·Experimental and Therapeutic Medicine·Wang ChaoWanhai Xu
Sep 1, 2005·Journal of Neuro-oncology·A MangiolaC Anile
Jan 31, 2006·Arquivos brasileiros de endocrinologia e metabologia·Julio Abucham, Teresa C Vieira
Oct 23, 2020·Experimental and Clinical Endocrinology & Diabetes : Official Journal, German Society of Endocrinology [and] German Diabetes Association·Hande Mefkure OzkayaPinar Kadioglu
Nov 27, 2020·Journal of the Endocrine Society·Amalina Haydar Ali TajuddinAhmad Marzuki Omar
Jan 21, 2021·Endocrine Practice : Official Journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists·Yael SoferYona Greenman

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