PMID: 19927999Nov 26, 2009Paper

Cellular renewal of the gastric mucosa in patients with chronic gastritis and portal hypertension

Ėksperimental'nai︠a︡ i klinicheskai︠a︡ gastroėnterologii︠a︡ = Experimental & clinical gastroenterology
L B LazebnikI O Koviazina

Abstract

Portal gastropathy is common finding in patients with portal hypertension (PH) caused by liver cirrhosis, but influence of H. pylori on pathogenesis and natural history of this lesion is still not completely cleared up. The goal of the study was to evaluate histological changes in gastric mucosa at the patients with liver cirrhosis and portal hypertension and to establish role of H. pylori in development of portal gastropathy and related atrophy of gastric mucosa. The gastric biopsy was obtained from 54 patients (36 men and 18 women) in the age from 22 till 73 years. The diagnosis of liver cirrhosis was confirmed at 39, and chronic hepatitis at 15 patients. H. pylori was revealed in 37 patients. Four groups of the patients were discharged: I - 11 patients without attributes PH; II - 12 patients with PH, but without esophageal varicose phlebectasia; III - 17 patients with a varicose phlebectasia of esophagus - grade I, and IV - 14 patients with a varicose phlebectasia of esophagus - grade II. Proliferative activity in gastric mucosa was evaluated by immunostain for Ki-67. Patients from group III had more prominent inflammation, but only 35% of them were H. pylori (+). Gastric mucosa atrophy was frequently observed in this group....Continue Reading

Related Concepts

Related Feeds

Atrophic Gastritis

Atrophic Gastritis is a process where gastric glandular cells are lost and replaced with firbous tissues, as a result of chronic inflammation. Learn more about Atrophic Gastritis here.