PMID: 374899Feb 1, 1979Paper

Cellular replication and aging

Mechanisms of Ageing and Development
E L SchneiderG Bynum

Abstract

Controversy exists concerning the effect of aging on replicating cell systems. This review summarizes a number of studies which indicate that both in vivo and in vitro, cell replication is significantly altered during aging. In vitro, studies of both human lymphocytes and fibroblasts indicated that a number of replication kinetic parameters are influenced by the age of the cell donor. In vivo, the application of the bromodeoxyuridine-(BrdU)-differential chromatid staining techniques to the analysis of cellular replication kinetics has permitted us to demonstrate that cellular replication is also significantly diminished with aging in mouse and rat cell populations. Therefore, both in vivo and in vitro in human as well as rodent cell populations, the rates of cellular replication are significantly decreased with cellular aging.

References

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Citations

Jan 1, 1981·Mechanisms of Ageing and Development·A F Stevenson, T Cremer
Dec 1, 2010·Cellular and Molecular Life Sciences : CMLS·Antero SalminenKai Kaarniranta
Jun 26, 2012·Mechanisms of Ageing and Development·Karolin KlementPeter Hemmerich
Oct 1, 1983·Journal of the American Academy of Dermatology·J H Epstein
May 1, 1982·Arteriosclerosis : an Official Journal of the American Heart Association, Inc·M A ReidyS M Schwartz
Feb 21, 2009·Journal of Applied Physiology·Jonas Rubenson, Richard L Marsh
Jul 18, 2019·PloS One·Tomasz FrackowiakPiotr Sorokowski
Aug 15, 2014·International Journal of Molecular Medicine·Shima MimuraTsutomu Masaki
Jul 21, 2020·Journal of Internal Medicine·J L Kirkland, T Tchkonia

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