Cellular reprogramming in farm animals: an overview of iPSC generation in the mammalian farm animal species

Journal of Animal Science and Biotechnology
J OgorevcP Dovč

Abstract

Establishment of embryonic stem cell (ESC) lines has been successful in mouse and human, but not in farm animals. Development of direct reprogramming technology offers an alternative approach for generation of pluripotent stem cells, applicable also in farm animals. Induced pluripotent stem cells (iPSCs) represent practically limitless, ethically acceptable, individuum-specific source of pluripotent cells that can be generated from different types of somatic cells. iPSCs can differentiate to all cell types of an organism's body and have a tremendous potential for numerous applications in medicine, agriculture, and biotechnology. However, molecular mechanisms behind the reprogramming process remain largely unknown and hamper generation of bona fide iPSCs and their use in human clinical practice. Large animal models are essential to expand the knowledge obtained on rodents and facilitate development and validation of transplantation therapies in preclinical studies. Additionally, transgenic animals with special traits could be generated from genetically modified pluripotent cells, using advanced reproduction techniques. Despite their applicative potential, it seems that iPSCs in farm animals haven't received the deserved attentio...Continue Reading

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Citations

May 10, 2016·Theriogenology·Lessly P Sepulveda-RinconNathalie Beaujean
Jul 6, 2017·Cytometry. Part a : the Journal of the International Society for Analytical Cytology·Y Z PatersonD J Guest
Jan 6, 2018·Circulation Research·Ergin BeyretJuan Carlos Izpisua Belmonte
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Sep 5, 2020·Saudi Journal of Biological Sciences·Muath Q Al-GhadiMohammed S Aleissa
Apr 21, 2021·The FEBS Journal·Michael Dannemann, Irene Gallego Romero

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Methods Mentioned

BETA
transgenic
transfections
PCR

Software Mentioned

ClustalW2

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