Cellular response to nano-structured Zr and ZrO2 alloyed layers on Ti-6Al-4V

Materials Science & Engineering. C, Materials for Biological Applications
Xiangyu ZhangPaul K Chu

Abstract

The surface topography of biomaterials is known to influence cellular response such as adhesion, spreading and differentiation. In this work, the behavior of osteoblasts and endothelial cells on nano-structured Zr and micro/nano-structured ZrO2 alloyed layers of Ti-6Al-4V (TC4) was investigated. Zr alloyed layer (Zr@TC4) decreases the hydrophilicity whereas ZrO2 alloyed layers (ZrO2@TC4) is more hydrophilic than TC4 and more proteins adsorb on ZrO2@TC4 followed by Zr@TC4. The cells proliferate steadily on the smooth TC4 and nano-structured Zr@TC4 surfaces and the osteoblast activity is more pronounced on Zr@TC4 than TC4. The micro/nano-structured surface on ZrO2@TC4 restricts cellular adhesion and spreading independent of the surface wettability and protein adsorption. The findings provide insights into the design of micro/nano-structured biomaterials and interfaces with controlled tissue response.

Citations

Nov 7, 2019·Journal of Biomedical Materials Research. Part B, Applied Biomaterials·Zhou YuJun Hu
Jan 11, 2020·Journal of Nanobiotechnology·Wenjing LiuLongquan Shao

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