PMID: 9552394Jan 1, 1996Paper

Cellular responses to antimetabolite anticancer agents: cytostasis versus cytotoxicity

Progress in Cell Cycle Research
Janet A Houghton, P J Houghton

Abstract

Thymineless death is an important cytotoxic response to several classes of antimetabolite agents used in the treatment of patients with carcinomas and hematopoeitic malignancies. Cell death induced by lack of dThd results in the formation of DNA nucleosomal ladders, and hence would be defined as a form of apoptosis. Although drug resistance to these agents has been extensively studied, relatively little attention has been focused on events downstream of dTTP depletion that determine the ultimate fate of the cancer cell. In this article we review some of the emerging data that suggests the role of p53 in determining whether the cellular response to dThd deprivation is cytostasis or cytotoxicity (apoptosis).

Citations

Apr 10, 2019·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Cecilia PozziStefano Mangani
Dec 14, 2018·Oxidative Medicine and Cellular Longevity·Jessica GambardellaDaniela Sorriento
Jun 12, 2003·Developmental Biology·Jennifer Schmahl, Blanche Capel

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