Cellular senescence as a therapeutic target to improve renal transplantation outcome

Pharmacological Research : the Official Journal of the Italian Pharmacological Society
Hester van WilligenburgRon W F de Bruin

Abstract

Kidney transplants from aged donors are more vulnerable to ischemic injury, suffer more from delayed graft function and have a lower graft survival compared to kidneys from younger donors. On a cellular level, aging results in an increase in cells that are in a permanent cell cycle arrest, termed senescence, which secrete a range of pro-inflammatory cytokines and growth factors. Consequently, these senescent cells negatively influence the local milieu by causing inflammaging, and by reducing the regenerative capacity of the kidney. Moreover, the oxidative damage that is inflicted by ischemia-reperfusion injury during transplantation can induce senescence and accelerate aging. In this review, we describe recent developments in the understanding of the biology of aging that have led to the development of a new class of therapeutic agents aimed at eliminating senescent cells. These compounds have already shown to be able to restore tissue homeostasis in old mice, improve kidney function and general health- and lifespan. Use of these anti-senescence compounds holds great promise to improve the quality of marginal donor kidneys as well as to remove senescent cells induced by ischemia-reperfusion injury. Altogether, senescent cell re...Continue Reading

Citations

Jan 10, 2020·Journal of Cellular and Molecular Medicine·Bingru ZhouPing Zou
Jul 21, 2020·Journal of Internal Medicine·J L Kirkland, T Tchkonia
Jun 8, 2018·Frontiers in Immunology·Héloïse CardinalMarie-Josée Hébert
Sep 7, 2018·Nature·Linda PartridgeP Eline Slagboom
Jan 2, 2019·Cellular and Molecular Life Sciences : CMLS·Ossama MoujaberUrsula Stochaj
Jul 18, 2018·International Journal of Molecular Sciences·Lies MoonenBenjamin A Vervaet
Sep 19, 2019·Cellular and Molecular Life Sciences : CMLS·Wen LiuBing Luo
Nov 11, 2020·Cells·Yohan SantinAngelo Parini
Jul 6, 2021·Frontiers in Immunology·Ross A CampbellKatie J Mylonas

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