Cellular senescence in the lung across the age spectrum

American Journal of Physiology. Lung Cellular and Molecular Physiology
Pavan ParikhY S Prakash

Abstract

Cellular senescence results in cell cycle arrest with secretion of cytokines, chemokines, growth factors, and remodeling proteins (senescence-associated secretory phenotype; SASP) that have autocrine and paracrine effects on the tissue microenvironment. SASP can promote remodeling, inflammation, infectious susceptibility, angiogenesis, and proliferation, while hindering tissue repair and regeneration. While the role of senescence and the contributions of senescent cells are increasingly recognized in the context of aging and a variety of disease states, relatively less is known regarding the portfolio and influences of senescent cells in normal lung growth and aging per se or in the induction or progression of lung diseases across the age spectrum such as bronchopulmonary dysplasia, asthma, chronic obstructive pulmonary disease, or pulmonary fibrosis. In this review, we introduce concepts of cellular senescence, the mechanisms involved in the induction of senescence, and the SASP portfolio that are relevant to lung cells, presenting the potential contribution of senescent cells and SASP to inflammation, hypercontractility, and remodeling/fibrosis: aspects critical to a range of lung diseases. The potential to blunt lung disease...Continue Reading

References

Jun 25, 1977·British Medical Journal·C Fletcher, R Peto
Sep 26, 1995·Proceedings of the National Academy of Sciences of the United States of America·G P DimriO Pereira-Smith
Feb 1, 1994·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·L Dow
Mar 1, 1996·American Journal of Respiratory and Critical Care Medicine·K C MeyerK Peterson
Aug 1, 1996·American Journal of Respiratory and Critical Care Medicine·K KuwanoN Hara
Apr 1, 1996·Seminars in Perinatology·D S Lambers, K E Clark
Oct 1, 1996·American Journal of Respiratory and Critical Care Medicine·I RahmanW MacNee
Nov 21, 1998·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·G SaretzkiB Villeponteau
Feb 17, 2001·American Journal of Respiratory and Critical Care Medicine·F D GillilandJ M Peters
Oct 11, 2001·Proceedings of the National Academy of Sciences of the United States of America·A KrtolicaJ Campisi
Jan 16, 2002·Current Opinion in Genetics & Development·Sarah Drayton, Gordon Peters
Dec 24, 2002·Trends in Immunology·Gilles KaplanskiCatherine Farnarier
Dec 24, 2002·American Journal of Respiratory Cell and Molecular Biology·Sarah M PuddicombeDonna E Davies
Dec 1, 1961·Experimental Cell Research·L HAYFLICK, P S MOORHEAD
Oct 1, 2003·The European Respiratory Journal·K AoshibaA Nagai
Oct 8, 2003·Respirology : Official Journal of the Asian Pacific Society of Respirology·Janet Stocks, Carol Dezateux
Jan 10, 2004·Advances in Experimental Medicine and Biology·Sarah A L Gebb, Peter Lloyd Jones
Aug 31, 2004·American Journal of Respiratory Cell and Molecular Biology·Takao TsujiAtsushi Nagai
Sep 21, 2004·American Journal of Physiology. Lung Cellular and Molecular Physiology·Minke van TuylMartin Post
Nov 3, 2004·The Journal of Clinical Investigation·Janakiraman KrishnamurthyNorman E Sharpless
Mar 1, 2005·Cell·Thomas B L Kirkwood
Mar 4, 2005·The International Journal of Biochemistry & Cell Biology·Ittai Ben-Porath, Robert A Weinberg
Aug 9, 2005·Developmental Dynamics : an Official Publication of the American Association of Anatomists·Sarah A GebbPeter Lloyd Jones
Aug 23, 2005·Lancet·A M ValdesT D Spector
Oct 21, 2005·Chest·Gavin C DonaldsonJadwiga A Wedzicha
Mar 2, 2006·The European Respiratory Journal·M MorláA G N Agustí
Jul 15, 2006·American Journal of Respiratory Cell and Molecular Biology·Toru NyunoyaGary W Hunninghake
Aug 2, 2006·The Journal of Biological Chemistry·Jean-Philippe CoppéChristian M Beauséjour
Aug 11, 2006·Arthritis Research & Therapy·Cem Gabay
Nov 23, 2006·Mechanisms of Ageing and Development·Jessie C JeyapalanUtz Herbig
Nov 23, 2006·Mechanisms of Ageing and Development·Claudio FranceschiStefano Salvioli
Feb 13, 2007·The Journal of Allergy and Clinical Immunology·Wendy C MooreUNKNOWN National Heart, Lung, Blood Institute's Severe Asthma Research Program
Mar 30, 2007·The New England Journal of Medicine·Mary Y ArmaniosJames E Loyd
Mar 31, 2007·Mechanisms of Ageing and Development·Torsten RichterThomas von Zglinicki
Apr 27, 2007·Proceedings of the National Academy of Sciences of the United States of America·Kalliopi D TsakiriChristine Kim Garcia
Feb 2, 2008·American Journal of Respiratory Cell and Molecular Biology·Hongwei YaoIrfan Rahman
Feb 19, 2008·Paediatric Respiratory Reviews·Louis I Landau
Mar 4, 2008·American Journal of Respiratory Cell and Molecular Biology·Timo QuanteAlaina J Ammit
Jun 3, 2008·Nature Cell Biology·Darren J BakerJan M van Deursen

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Citations

Sep 12, 2019·American Journal of Physiology. Lung Cellular and Molecular Physiology·Jennifer M S Sucre, Erin J Plosa
Mar 5, 2020·Antioxidants & Redox Signaling·Karen Bernard, Victor J Thannickal
May 10, 2020·International Journal of Molecular Sciences·Christine HanselDiana Klein
Jun 9, 2020·Frontiers in Medicine·Kenneth P HoughVictor J Thannickal
Aug 29, 2019·American Journal of Physiology. Lung Cellular and Molecular Physiology·Rim S J SarkerAli Önder Yildirim
Oct 10, 2019·American Journal of Physiology. Lung Cellular and Molecular Physiology·Ettore LignelliRory E Morty
Feb 23, 2020·Circulation Research·Haobo LiAnthony Rosenzweig
Apr 3, 2020·American Journal of Physiology. Lung Cellular and Molecular Physiology·Y S Prakash
Aug 11, 2020·The Journal of Cell Biology·Sergio Piñeiro-HermidaMaria A Blasco
Dec 19, 2019·Frontiers in Immunology·Karan SachdevaPeisong Gao
Mar 21, 2019·American Journal of Physiology. Lung Cellular and Molecular Physiology·Rory E Morty, Y S Prakash
Mar 3, 2020·Frontiers in Cell and Developmental Biology·Zhao-Ni WangZhuang-Gui Chen
Sep 3, 2020·American Journal of Physiology. Lung Cellular and Molecular Physiology·Tolga YaziciogluChristina Brandenberger
Oct 31, 2020·Frontiers in Immunology·Jon Hazeldine, Janet M Lord
Dec 8, 2020·Frontiers in Medicine·Alessandro Venosa
Apr 16, 2021·Frontiers in Immunology·Nick P GoplenJie Sun
Apr 28, 2021·Physiology·M L Koloko NgassieJ K Burgess
May 4, 2021·Frontiers in Pharmacology·Lisa KünziStefanie Krick
Jun 8, 2021·Women's Health·Tiziana CiarambinoMauro Giordano
Oct 7, 2021·Microbiology Spectrum·Konstantina KitsouGkikas Magiorkinis
Nov 9, 2021·Frontiers in Cellular and Infection Microbiology·Sheryl Erica Fernandes, Deepak Kumar Saini
Nov 16, 2021·Frontiers in Physiology·Sandrine GremlichJohannes C Schittny
Jan 28, 2022·Scientific Reports·Kathrin KahnertUNKNOWN COSYCONET Study Group

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Methods Mentioned

BETA
RNA Seq
flow cytometry
biopsies
bronchoalveolar lavage
transgenic

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