Cellular Senescence-Inducing Small Molecules for Cancer Treatment

Current Cancer Drug Targets
Peng LiuZhigang Tu

Abstract

Recently, the chemotherapeutic drug-induced cellular senescence has been considered a promising anti-cancer approach. The drug-induced senescence, which shows both similar and different hallmarks from replicative and oncogene-induced senescence, was regarded as a key determinant of tumor response to chemotherapy in vitro and in vivo. To date, an amount of effective chemotherapeutic drugs that can evoke senescence in cancer cells have been reported. The targets of these drugs differ substantially, including senescence signaling pathways, DNA replication process, DNA damage pathways, epigenetic modifications, microtubule polymerization, senescence-associated secretory phenotype (SASP), and so on. By summarizing senescence-inducing small molecule drugs together with their specific traits and corresponding mechanisms, this review is devoted to inform scientists to develop novel therapeutic strategies against cancer through inducing senescence.

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Citations

Jun 5, 2019·International Journal of Molecular Sciences·Yu-Hsuan LeeRong-Jane Chen
Jun 16, 2021·Biochemical Pharmacology·Alfonso Serrano-Del ValleIsabel Marzo
Aug 8, 2021·International Journal of Molecular Sciences·Angel CayoNelson Brown
Aug 14, 2021·Phytomedicine : International Journal of Phytotherapy and Phytopharmacology·Jingfeng LiuJian Chen

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