PMID: 42918Dec 1, 1979

Cellular site of gastric acid secretion

Proceedings of the National Academy of Sciences of the United States of America
D R DibonaG Sachs

Abstract

Isolated gastric glands of the rabbit were examined both with differential interference-contrast microscopy and with electron microscopy to describe the morphologic correlates of acid secretion. Stimulation of the glands with histamine resulted in the development of intracellular spaces within the parietal cells. A similar transformation was produced by addition of 1 mM aminopyrine, whether the weak base was added in the presence of normal-K+ (5.4 mM) or high-K+ (108 mM) solutions. The intracellular space was compatible with the expanded canaliculus described in stimulated parietal cells. Confirmation that the space produced by histamine is the site of acid secretion was gained by combining fluorescence and interference-contrast methods in the presence of the dye acridine orange, which displays a pH-dependent metachromasia in its emission spectrum. Human gastrin I resulted in an observable discharge of peptic granules.

References

Feb 1, 1979·Proceedings of the National Academy of Sciences of the United States of America·D LichtshteinA J Blume
Feb 1, 1976·Acta Physiologica Scandinavica·T Berglindh, K J Obrink
Feb 1, 1972·Archives of Internal Medicine·W S Rehm

Citations

Jun 1, 1989·Pflügers Archiv : European journal of physiology·H SakaiN Takeguchi
Sep 1, 1985·Pflügers Archiv : European journal of physiology·T SchettinoE Frömter
Feb 1, 1995·Digestive Diseases and Sciences·B I HirschowitzG Sachs
Dec 1, 1985·Calcified Tissue International·R E AndersonD M Woodbury
Oct 1, 1986·Calcified Tissue International·R E AndersonW S Jee
Jan 11, 1984·Biochimica Et Biophysica Acta·M LjungströmS Mårdh
Aug 5, 1991·Biochimica Et Biophysica Acta·Y KawasakiM Ohara-Imaizumi
Mar 31, 1992·Biochemical and Biophysical Research Communications·J L CaberoS Mårdh
Dec 21, 2000·Trends in Pharmacological Sciences·G SachsK Melchers
Feb 27, 2001·Comparative Biochemistry and Physiology. Part A, Molecular & Integrative Physiology·L AzerkanS Mårdh
Sep 1, 1981·Proceedings of the National Academy of Sciences of the United States of America·D H MalinowskaG Sachs
Jul 1, 1982·Proceedings of the National Academy of Sciences of the United States of America·S GluckQ al-Awqati
May 1, 1980·The Journal of Cell Biology·T BerglindhG Sachs
Jan 2, 1997·The EMBO Journal·D T DransfieldJ R Goldenring
Aug 27, 1982·Biochimica Et Biophysica Acta·R J Jackson, G Sachs
Jul 1, 1988·Baillière's Clinical Gastroenterology·H F Helander
Dec 1, 1981·The Journal of Surgical Research·T K Ray, D Fromm
Jan 1, 1980·Annals of the New York Academy of Sciences·G SachsG Saccomani
Jan 1, 1980·Annals of the New York Academy of Sciences·G SachsG Saccomani
Jun 1, 1988·Bioscience Reports·C GespachE Chastre
Dec 23, 2004·Physiological Genomics·Nils W G LambrechtG Sachs
May 31, 2007·Physiological Genomics·Nils W G LambrechtG Sachs
Nov 20, 1998·Journal of Pediatric Gastroenterology and Nutrition·D M Israel, E Hassall
Oct 29, 2000·American Journal of Physiology. Gastrointestinal and Liver Physiology·C AthmannG Sachs
May 1, 1991·The American Journal of Physiology·G SaccomaniR L Shoemaker
May 1, 1982·The American Journal of Physiology·C S Pace, G Sachs
Nov 11, 1994·The American Journal of Physiology·A ThibodeauJ G Forte

Related Concepts

C.I. Basic Orange 14
Eufibron
Chloride Ion Level
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Structure of Pyloric Gland
Ceplene
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Secretory Rate

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