PMID: 42918Dec 1, 1979

Cellular site of gastric acid secretion

Proceedings of the National Academy of Sciences of the United States of America
D R DibonaG Sachs


Isolated gastric glands of the rabbit were examined both with differential interference-contrast microscopy and with electron microscopy to describe the morphologic correlates of acid secretion. Stimulation of the glands with histamine resulted in the development of intracellular spaces within the parietal cells. A similar transformation was produced by addition of 1 mM aminopyrine, whether the weak base was added in the presence of normal-K+ (5.4 mM) or high-K+ (108 mM) solutions. The intracellular space was compatible with the expanded canaliculus described in stimulated parietal cells. Confirmation that the space produced by histamine is the site of acid secretion was gained by combining fluorescence and interference-contrast methods in the presence of the dye acridine orange, which displays a pH-dependent metachromasia in its emission spectrum. Human gastrin I resulted in an observable discharge of peptic granules.


Feb 1, 1979·Proceedings of the National Academy of Sciences of the United States of America·D LichtshteinA J Blume
Feb 1, 1976·Acta Physiologica Scandinavica·T Berglindh, K J Obrink
Feb 1, 1972·Archives of Internal Medicine·W S Rehm


Jun 1, 1989·Pflügers Archiv : European journal of physiology·H SakaiN Takeguchi
Sep 1, 1985·Pflügers Archiv : European journal of physiology·T SchettinoE Frömter
Feb 1, 1995·Digestive Diseases and Sciences·B I HirschowitzG Sachs
Dec 1, 1985·Calcified Tissue International·R E AndersonD M Woodbury
Oct 1, 1986·Calcified Tissue International·R E AndersonW S Jee
Jan 11, 1984·Biochimica Et Biophysica Acta·M LjungströmS Mårdh
Aug 5, 1991·Biochimica Et Biophysica Acta·Y KawasakiM Ohara-Imaizumi
Mar 31, 1992·Biochemical and Biophysical Research Communications·J L CaberoS Mårdh
Dec 21, 2000·Trends in Pharmacological Sciences·G SachsK Melchers
Feb 27, 2001·Comparative Biochemistry and Physiology. Part A, Molecular & Integrative Physiology·L AzerkanS Mårdh
Sep 1, 1981·Proceedings of the National Academy of Sciences of the United States of America·D H MalinowskaG Sachs
Jul 1, 1982·Proceedings of the National Academy of Sciences of the United States of America·S GluckQ al-Awqati
May 1, 1980·The Journal of Cell Biology·T BerglindhG Sachs
Jan 2, 1997·The EMBO Journal·D T DransfieldJ R Goldenring
Aug 27, 1982·Biochimica Et Biophysica Acta·R J Jackson, G Sachs
Jul 1, 1988·Baillière's Clinical Gastroenterology·H F Helander
Dec 1, 1981·The Journal of Surgical Research·T K Ray, D Fromm
Jan 1, 1980·Annals of the New York Academy of Sciences·G SachsG Saccomani
Jan 1, 1980·Annals of the New York Academy of Sciences·G SachsG Saccomani
Jun 1, 1988·Bioscience Reports·C GespachE Chastre
Dec 23, 2004·Physiological Genomics·Nils W G LambrechtG Sachs
May 31, 2007·Physiological Genomics·Nils W G LambrechtG Sachs
Nov 20, 1998·Journal of Pediatric Gastroenterology and Nutrition·D M Israel, E Hassall
Oct 29, 2000·American Journal of Physiology. Gastrointestinal and Liver Physiology·C AthmannG Sachs
May 1, 1991·The American Journal of Physiology·G SaccomaniR L Shoemaker
May 1, 1982·The American Journal of Physiology·C S Pace, G Sachs
Nov 11, 1994·The American Journal of Physiology·A ThibodeauJ G Forte

Related Concepts

C.I. Basic Orange 14
Chloride Ion Level
Gastric Juice
Structure of Pyloric Gland
Hydrogen-Ion Concentration
Secretory Rate

Trending Feeds


Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Synthetic Genetic Array Analysis

Synthetic genetic arrays allow the systematic examination of genetic interactions. Here is the latest research focusing on synthetic genetic arrays and their analyses.

Congenital Hyperinsulinism

Congenital hyperinsulinism is caused by genetic mutations resulting in excess insulin secretion from beta cells of the pancreas. Here is the latest research.

Neural Activity: Imaging

Imaging of neural activity in vivo has developed rapidly recently with the advancement of fluorescence microscopy, including new applications using miniaturized microscopes (miniscopes). This feed follows the progress in this growing field.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Epigenetic Memory

Epigenetic memory refers to the heritable genetic changes that are not explained by the DNA sequence. Find the latest research on epigenetic memory here.

Cell Atlas of the Human Eye

Constructing a cell atlas of the human eye will require transcriptomic and histologic analysis over the lifespan. This understanding will aid in the study of development and disease. Find the latest research pertaining to the Cell Atlas of the Human Eye here.

Femoral Neoplasms

Femoral Neoplasms are bone tumors that arise in the femur. Discover the latest research on femoral neoplasms here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Related Papers

The Journal of Cell Biology
T BerglindhG Sachs
Comparative Biochemistry and Physiology. Part A, Molecular & Integrative Physiology
P BengtssonS Mårdh
Annals of the New York Academy of Sciences
S L BontingJ J Schrijen
© 2021 Meta ULC. All rights reserved