Cellular stress and apoptosis contribute to the pathogenesis of autism spectrum disorder

Autism Research : Official Journal of the International Society for Autism Research
Daoyin DongPeixin Yang

Abstract

The molecular pathogenesis of autism spectrum disorder, a neurodevelopmental disorder, is still elusive. In this study, we investigated the possible roles of endoplasmic reticulum (ER) stress, oxidative stress, and apoptosis as molecular mechanisms underlying autism. This study compared the activation of ER stress signals (protein kinase R-like endoplasmic reticulum kinase [PERK], activating transcription factor 6 [ATF6], inositol-requiring enzyme 1 alpha [IRE1α]) in different brain regions (prefrontal cortex, hippocampus, cerebellum) in subjects with autism and in age-matched controls. Our data showed that the activation of three signals of ER stress varies in different regions of the autistic brain. IRE1α was activated in cerebellum and prefrontal cortex but ATF6 was activated in hippocampus. PERK was not activated in the three regions. Furthermore, the activation of ER stress was confirmed because the expression of C/EBP-homologous protein (CHOP), which is the common downstream indicators of ER stress signals, and most of ER chaperones were upregulated in the three regions. Consistent with the induction of ER stress, apoptosis was found in the three regions by detecting the cleavage of caspase 8 and poly(ADP-ribose) polymera...Continue Reading

References

Feb 15, 2001·Molecular Psychiatry·S H FatemiT McMenomy
Apr 17, 2001·Neuroreport·S H FatemiM Jalali-Mousavi
Nov 20, 2002·The Journal of Clinical Investigation·Randal J Kaufman
Feb 13, 2003·Cell Biochemistry and Function·Süleyman Salih ZoroğluOmer Akyol
Apr 2, 2003·Nature Genetics·Stéphane JamainUNKNOWN Paris Autism Research International Sibpair Study
Apr 15, 2003·Clinica Chimica Acta; International Journal of Clinical Chemistry·Sadik SöğütOmer Akyol
Feb 13, 2004·Biological Psychiatry·Thayne L SweetenChristopher J McDougle
Sep 15, 2004·Journal of Chemical Neuroanatomy·Yanjun Ma, Linda M Hendershot
Dec 9, 2004·The American Journal of Clinical Nutrition·S Jill JamesJames A Neubrander
Feb 5, 2005·Toxicology·Amy Bishop, James E Anderson
Mar 8, 2005·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·Margaret L Bauman, Thomas L Kemper
Jun 13, 2006·Pathophysiology : the Official Journal of the International Society for Pathophysiology·Abha Chauhan, Ved Chauhan
Sep 6, 2006·EMBO Reports·Eva SzegezdiAfshin Samali
Jan 12, 2007·Journal of Autism and Developmental Disorders·Michelle SullivanRebecca Landa
May 8, 2007·FEBS Letters·Min Ni, Amy S Lee
Oct 25, 2007·Biochemical Society Transactions·J P BolañosA Almeida
Oct 30, 2007·Neuron·Eric CourchesneJohn Morgan
Oct 30, 2008·Biochemical and Biophysical Research Communications·Yu ZhilingMariko Y Momoi
Jul 22, 2010·Journal of Neuroscience Research·Ashfaq M SheikhXiaohong Li
Dec 24, 2010·Cell Communication and Signaling : CCS·Ganta Vijay ChaitanyaPhanithi Prakash Babu
Apr 19, 2011·Annual Review of Biochemistry·Ineke Braakman, Neil J Bulleid
Apr 27, 2011·Journal of Autism and Developmental Disorders·Stepan MelnykS Jill James
Mar 29, 2012·Journal of Autism and Developmental Disorders·Lonnie ZwaigenbaumCaroline Roncadin
Jan 22, 2013·Neurobiology of Disease·Guomei TangDavid Sulzer
Feb 23, 2013·Apoptosis : an International Journal on Programmed Cell Death·Susan E LogueAfshin Samali
Jul 16, 2013·Biochimica Et Biophysica Acta·Renata Sano, John C Reed
Jan 8, 2014·Autism Research and Treatment·Joanna C HamlinS Jill James
Feb 26, 2014·Journal of the American Academy of Child and Adolescent Psychiatry·Thomas W FrazierAntonio Y Hardan
Apr 10, 2014·Biomarkers in Medicine·Richard E Frye, S Jill James

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Citations

Feb 14, 2020·PLoS Genetics·Mayanglambam Dhruba SinghSanthosh Girirajan
Apr 5, 2020·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Alessandra PecorelliGiuseppe Valacchi
Apr 18, 2020·Molecular Autism·Aaron Gordon, Daniel H Geschwind
Aug 1, 2019·Journal of Molecular Neuroscience : MN·Mohammad Mahdi EftekharianSoudeh Ghafouri-Fard
May 24, 2020·Brain Sciences·Ahmad Naqib ShuidIsa Naina Mohamed
Nov 5, 2020·Autism : the International Journal of Research and Practice·Amy Niego, Antonio Benítez-Burraco
Jan 16, 2021·Journal of Endocrinological Investigation·A A E MarcondesM O Ribeiro
Jan 26, 2021·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Geir BjørklundSalvatore Chirumbolo
Nov 3, 2020·Frontiers in Cellular Neuroscience·Vignesh SrinivasanDan Lindholm
May 17, 2021·Neurochemistry International·Aarti Sharma, Sidharth Mehan
Jul 10, 2021·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·Júlio Santos-TerraCarmem Gottfried
Aug 25, 2021·Metabolic Brain Disease·Bei ZhangLin Xue
Nov 23, 2021·Frontiers in Neuroscience·Julia Reichard, Geraldine Zimmer-Bensch
Jan 11, 2022·IScience·Thomaz Lüscher-DiasHelder I Nakaya

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