Cellular Stress Associated with Aneuploidy

Developmental Cell
Jin ZhuRong Li

Abstract

Aneuploidy, chromosome stoichiometry that deviates from exact multiples of the haploid compliment of an organism, exists in eukaryotic microbes, several normal human tissues, and the majority of solid tumors. Here, we review the current understanding about the cellular stress states that may result from aneuploidy. The topics of aneuploidy-induced proteotoxic, metabolic, replication, and mitotic stress are assessed in the context of the gene dosage imbalance observed in aneuploid cells. We also highlight emerging findings related to the downstream effects of aneuploidy-induced cellular stress on the immune surveillance against aneuploid cells.

Citations

Jun 28, 2018·Cancer Science·Kozo TanakaMasaki Inagaki
Jun 5, 2019·Critical Reviews in Biochemistry and Molecular Biology·Mark R Sullivan, Matthew G Vander Heiden
Jun 28, 2019·Cell Cycle·Rita BrásLuís Pedro Resende
May 24, 2019·Free Radical Research·David L NewmanStephen L Gregory
Sep 25, 2019·Nature Reviews. Genetics·Uri Ben-David, Angelika Amon
Jun 3, 2020·Open Biology·Stephan U Gerlach, Héctor Herranz
Jun 14, 2020·Genes·Therese WilhelmValeria Naim
Dec 5, 2018·Current Genetics·Carine Beaupere, Vyacheslav M Labunskyy
Oct 3, 2018·Human Genetics·Maria Clara BonagliaOrsetta Zuffardi
Jan 4, 2019·Nature Cell Biology·Narendra Kumar Chunduri, Zuzana Storchová
Sep 22, 2019·International Journal of Molecular Sciences·David L Newman, Stephen L Gregory
Nov 6, 2018·Frontiers in Immunology·Ibrahim Al BakirTrevor A Graham
Jul 10, 2019·Annual Review of Cell and Developmental Biology·Fong Kuan Wong, Oscar Marín
Aug 28, 2020·Cancers·Claudio Brancolini, Luca Iuliano
Dec 5, 2018·Genes & Development·Zuzana Storchova
Jun 13, 2020·Nature Communications·Shruti SinglaMagdalena Zernicka-Goetz
Dec 1, 2020·BMC Biology·Yu-Hsuan ChengJun-Yi Leu
Jan 21, 2021·International Journal of Molecular Sciences·Xing-Xing TangDao-Qiong Zheng
Jan 13, 2021·Nature Reviews. Cancer·Anand VasudevanJason M Sheltzer
Feb 24, 2021·The Journal of Cell Biology·Roshan L ShresthaMunira A Basrai
Jul 11, 2020·Trends in Cell Biology·Donald T FoxYves Van de Peer
Mar 14, 2021·The Journal of Biological Chemistry·Sophie L CookeRobertus A M de Bruin
Oct 16, 2020·Molecular Biology Reports·Banafsheh Mirzaei-SereshtSepideh Mollammohammadi
Oct 25, 2020·Trends in Genetics : TIG·Anna J MoyerRoger H Reeves
Apr 7, 2021·Seminars in Cell & Developmental Biology·Zuzana Storchova
May 7, 2021·Molecular Oncology·Matheus Henrique Dias, René Bernards
May 25, 2021·Molecular & Cellular Oncology·Yael Cohen-Sharir, Uri Ben-David
May 24, 2021·Journal of Genetics and Genomics = Yi Chuan Xue Bao·Kevin Christian Montecillo GulayTakashi Kimura
Aug 6, 2021·Developmental Cell·Marica Rosaria IppolitoStefano Santaguida
Sep 2, 2021·Nature Communications·Lindsay N Redman-RiveraJennifer A Pietenpol
Sep 24, 2021·Nature Communications·Narendra Kumar ChunduriZuzana Storchova

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Recent Results in Cancer Research. Fortschritte Der Krebsforschung. Progrès Dans Les Recherches Sur Le Cancer
Eduardo M Torres
Pediatric Dermatology
Dawn H Siegel, Virginia P Sybert
© 2022 Meta ULC. All rights reserved