Cellular therapy with human autologous adipose-derived adult cells of stromal vascular fraction for alopecia areata

Stem Cell Research & Therapy
Rami AnderiAline Hamade

Abstract

Most common forms of hair loss (alopecia) are caused by aberrant hair follicle cycling and changes in hair follicle morphology. However, current treatments for alopecia do not specifically target these processes. Adipose-derived stromal vascular cells (ADSVCs) that can be harvested from fat cells are one of the latest breakthroughs in the aesthetic field. The potential use of stem cell-based therapies (SCBT) for the repair and regeneration of various tissues and organs offers a paradigm shift that may provide alternative therapeutic solutions, which can be applied to prevent hair loss. This study aimed to present clinical cases of SCBT for the treatment of alopecia areata by transplantation of ADSVCs in the scalp. Twenty patients (9 women and 11 men) were recruited to our retrospectively registered study. After lipoaspiration, autologous ADSVCs were generated and characterized before the injection of 4-4.7 ×  106 cells into the scalp of the patient. Hair regeneration was assessed by three clinical tests: the pull test, hair quality, and hair density. All patients experienced hair regeneration, increased hair growth and decreased pull test 3 and 6 months after the treatment with ADSVCs [hair density (85.1 ± 8.7 vs 121.1 ± 12.5 h...Continue Reading

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Citations

Jul 10, 2018·Aesthetic Surgery Journal·Graeme Ewan Glass, Patrizia Ferretti
May 28, 2019·International Journal of Molecular Sciences·Loubna MaziniGabriel Malka
Jul 19, 2020·Experimental Dermatology·Marta BertoliniRalf Paus
Jul 30, 2020·Stem Cells International·Luiz Charles-de-SáGino Rigotti
Aug 30, 2018·Stem Cells International·Agnieszka Owczarczyk-SaczonekJoanna Wojtkiewicz
Apr 24, 2020·Drugs·Aunna Pourang, Natasha Atanaskova Mesinkovska
May 22, 2019·Aesthetic Surgery Journal·Nina Semsarzadeh, Shilpi Khetarpal
Dec 29, 2020·Journal of Cosmetic Dermatology·Mohammad Ali NilforoushzadehAmir Reza Hanifnia
Dec 17, 2020·The Journal of Investigative Dermatology·Rachael WilliamsM Julie Thornton
Nov 14, 2020·International Journal of Molecular Sciences·Antonio Martinez-LopezSalvador Arias-Santiago
Jun 1, 2021·Dermatologic Clinics·Aditya K GuptaJeffrey A Rapaport
Jul 11, 2021·Indian Journal of Dermatology, Venereology and Leprology·Sujay KhandpurD R Gunaabalaji
May 3, 2020·Experimental Dermatology·Rachael WilliamsM Julie Thornton

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Methods Mentioned

BETA
flow cytometry

Software Mentioned

SPSS

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