Cellular Transport and Bioactivity of a Major Saffron Apocarotenoid, Picrocrocin (4-(β-D-Glucopyranosyloxy)-2,6,6-trimethyl-1-cyclohexene-1-carboxaldehyde)

Journal of Agricultural and Food Chemistry
Anastasia KyriakoudiNora M O'Brien

Abstract

The cellular transport and bioactivity of the second major saffron apocarotenoid, picrocrocin, was examined in parallel to that of the major group, crocetin sugar esters, in aqueous extracts. The transport of pure picrocrocin was investigated in comparison to that of other saffron apocarotenoids, trans-crocetin (di-β-D-gentiobiosyl) ester and crocetin using the Caco-2 cell model coupled with an in vitro digestion procedure. RP-HPLC-DAD was employed to quantify the bioaccessible and bioavailable amounts of individual apocarotenoids. Picrocrocin and crocetin sugar esters though highly bioaccessible (75% and 60%, respectively) were transported at minute quantities (0.2% and 0.5%, respectively; 10-fold lower than crocetin). Picrocrocin did not protect against oxidant-induced DNA damage in U937, human monocytic blood cells at the concentration investigated, however, it reduced the proliferation of human adenocarcinoma and hepatocarcinoma cells. Our findings may be useful for the requirements of food legislation regarding saffron preparations, in which both apocarotenoid groups coexist.

References

Apr 18, 2000·European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences·S YamashitaH Tokuda
Jan 5, 2002·Cell Biology and Toxicology·Y SambruyI De Angelis
Jul 9, 2004·Critical Reviews in Food Science and Nutrition·Mario Giaccio
Nov 13, 2004·Journal of Agricultural and Food Chemistry·Jeanelle BoyerRui Hai Liu
Feb 3, 2005·Journal of Agricultural and Food Chemistry·Caroline HenryJean-Michel Mérillon
Jan 12, 2007·Phytomedicine : International Journal of Phytotherapy and Phytopharmacology·Liang XiJian Fu
Mar 10, 2009·Methods : a Companion to Methods in Enzymology·Wenjuan LiaoWei-Guo Zhu
Mar 17, 2009·Journal of Agricultural and Food Chemistry·Stella A OrdoudiMaria Z Tsimidou
Apr 28, 2009·Journal of Photochemistry and Photobiology. B, Biology·C D KanakisM G Polissiou
Apr 8, 2010·Mini Reviews in Medicinal Chemistry·Song Gao, Ming Hu
May 19, 2010·International Journal of Molecular Sciences·Massimo D'ArchivioRoberta Masella
Dec 15, 2010·Journal of Agricultural and Food Chemistry·Ana M SánchezGonzalo L Alonso
Mar 15, 2011·Journal of Pharmaceutical and Biomedical Analysis·Dimitra G ChryssanthiPaul Cordopatis
Apr 7, 2011·Current Pharmaceutical Biotechnology·William G GutheilAnimesh Dhar
Jul 1, 1999·Environmental Toxicology and Pharmacology·A SteensmaH A Kuiper
Oct 12, 2012·The American Journal of Clinical Nutrition·Johannes von Lintig
Oct 27, 2012·Asian Pacific Journal of Cancer Prevention : APJCP·Cai-Yan LiHui-Hui Li
Nov 14, 2012·Analytica Chimica Acta·Anastasia KyriakoudiMaria Z Tsimidou
May 10, 2013·Journal of Agricultural and Food Chemistry·Anastasia KyriakoudiNora M O'Brien
Sep 26, 2013·Pharmaceutical Research·Charity J WallaceMohamed E H ElSayed
Nov 26, 2013·Biochimica Et Biophysica Acta·Azam BolhassaniS Zahra Bathaie
Nov 28, 2013·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Seyedeh Hoda Alavizadeh, Hossein Hosseinzadeh
Aug 7, 2014·Proceedings of the National Academy of Sciences of the United States of America·Sarah FruscianteGiovanni Giuliano
Feb 1, 2015·Phytomedicine : International Journal of Phytotherapy and Phytopharmacology·M LautenschlägerA Hensel
Feb 28, 2015·Archives of Biochemistry and Biophysics·M Luisa BonetAndreu Palou
Jan 1, 2013·Antioxidants·Ehab A Abourashed

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Citations

Jan 4, 2018·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·María José BagurGonzalo L Alonso
Nov 15, 2017·European Journal of Drug Metabolism and Pharmacokinetics·Azar HosseiniHossein Hosseinzadeh
May 13, 2018·Annual Review of Nutrition·Earl H Harrison, Loredana Quadro
Aug 7, 2019·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Natalia Moratalla-LópezGonzalo L Alonso
Feb 3, 2018·Electrophoresis·Anastasia Kyriakoudi, Maria Z Tsimidou
Sep 14, 2018·Oxidative Medicine and Cellular Longevity·Marcela Silva Dos SantosAlexandre de Barros Falcão Ferraz
Feb 25, 2020·Evidence-based Complementary and Alternative Medicine : ECAM·Paula AlmodóvarAntonio M Inarejos-García
Dec 29, 2020·Critical Reviews in Food Science and Nutrition·Débora Cerdá-BernadMaría José Frutos
Jul 28, 2021·Metabolism Open·Alexios-Fotios A MentisMoschos G Polissiou

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