Cellulose Abetted Assembly and Temporally Decoupled Loading of Cargo into Vesicles Synthesized from Functionally Diverse Lamellar Phase Forming Amphiphiles

Biomacromolecules
Alexander LiAnand Bala Subramaniam

Abstract

Self-assembled micrometer-scale vesicles composed of lamellar phase forming amphiphiles are useful as chemical microreactors, as minimal artificial cells, as protocell mimics for studies of the origins of life, and as vehicles for the targeted delivery of drugs. Given their varied uses, discovery of a universal mechanism that is simple, rapid, and that produces vesicles from a large variety of amphiphiles with different chemical and physical properties at high yield is extremely desirable. Here we show that cellulose, in the form of cellulose paper, facilitates the assembly of membranous vesicles 5-20 μm in diameter from scientifically and technologically important amphiphiles of diverse chemical structures and functionality such as fatty acids (fatty acid vesicles), amphiphilic diblock copolymers, and amphiphilic triblock copolymers (polymersomes). Assembly of vesicles occurred within 90 min of placing the amphiphile-coated cellulose paper into aqueous solutions. Varying thermal and chemical conditions, however, are required for the high-yield assembly of vesicles from the different amphiphiles. The vesicles, when attached to cellulose fibers, have membranes that remain unsealed. This topological characteristic of the vesicles...Continue Reading

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Citations

Jul 28, 2018·Chemical Communications : Chem Comm·Sun Hae Ra ShinWalter F Paxton
Nov 18, 2018·Langmuir : the ACS Journal of Surfaces and Colloids·Joseph PazziAnand Bala Subramaniam
Dec 8, 2020·ACS Applied Materials & Interfaces·Joseph Pazzi, Anand Bala Subramaniam
Jul 6, 2019·Langmuir : the ACS Journal of Surfaces and Colloids·Vaishnavi GirishAnand Bala Subramaniam
Jul 3, 2018·Langmuir : the ACS Journal of Surfaces and Colloids·Nareh MovsesianNoah Malmstadt

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