Cellulose acetate based 3-dimensional electrospun scaffolds for skin tissue engineering applications

Carbohydrate Polymers
Deniz AtilaAyşen Tezcaner

Abstract

Skin defects that are not able to regenerate by themselves are among the major problems faced. Tissue engineering approach holds promise for treating such defects. Development of tissue-mimicking-scaffolds that can promote healing process receives an increasing interest in recent years. In this study, 3-dimensional electrospun cellulose acetate (CA) pullulan (PULL) scaffolds were developed for the first time. PULL was intentionally used to obtain 3D structures with adjustable height. It was removed from the electrospun mesh to increase the porosity and biostability. Different ratios of the polymers were electrospun and analyzed with respect to degradation, porosity, and mechanical properties. It has been observed that fiber diameter, thickness and porosity of scaffolds increased with increased PULL content, on the other hand this resulted with higher degradation of scaffolds. Mechanical strength of scaffolds was improved after PULL removal suggesting their suitability as cell carriers. Cell culture studies were performed with the selected scaffold group (CA/PULL: 50/50) using mouse fibroblastic cell line (L929). In vitro cell culture tests showed that cells adhered, proliferated and populated CA/PULL (50/50) scaffolds showing t...Continue Reading

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Citations

Aug 27, 2016·Carbohydrate Polymers·Ram Sarup SinghJohn F Kennedy
Sep 11, 2016·Materials Science & Engineering. C, Materials for Biological Applications·Deniz AtilaAyşen Tezcaner
Jan 28, 2017·Burns and Trauma·Maedeh RahimnejadWen Zhong
May 14, 2016·Biofabrication·Jochen WalserStephen J Ferguson
Aug 11, 2019·International Journal of Molecular Sciences·Simona-Rebeca IgnatMarieta Costache
Mar 14, 2020·Wiley Interdisciplinary Reviews. Nanomedicine and Nanobiotechnology·Antonios KeirouzNorbert Radacsi
Dec 2, 2020·Materials Science & Engineering. C, Materials for Biological Applications·Ana Elisa Antunes Dos SantosRoberta Viana Ferreira
Nov 3, 2020·International Journal of Biological Macromolecules·Ram Sarup SinghJohn F Kennedy
Feb 2, 2021·International Journal of Pharmaceutics·Duygu Deniz Akolpoğlu BaşaranDilek Keskin
Feb 7, 2021·Materials Science & Engineering. C, Materials for Biological Applications·A Izadyari AghmiuniAzim AkbarzadehKhiyavi
Dec 19, 2020·International Journal of Nanomedicine·Silvia TortorellaErica Locatelli
Jun 22, 2019·International Journal of Biological Macromolecules·Suhail AhmadSaiqa Ikram
Sep 28, 2017·Journal of Agricultural and Food Chemistry·Peng WenHong Wu

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