Cellulose acetate/poly lactic acid coaxial wet-electrospun scaffold containing citalopram-loaded gelatin nanocarriers for neural tissue engineering applications

International Journal of Biological Macromolecules
Mahdi Naseri-NosarShahriar Hojjati-Emami

Abstract

The current study aimed to develop a biodegradable three-dimensional drug-loaded scaffold with the core-shell structured fibrils using coaxial wet-electrospinning for neural tissue engineering application. Poly lactic acid was wet-electrospun as the core, whereas cellulose acetate was fabricated into the fibril's shell. The scaffold then was coated with the citalopram-loaded gelatin nanocarriers (CGNs) produced by nanoprecipitation method. Scanning electron microscope observation revealed that the fibrils formed a nonwoven structure with the average diameter of ∼950nm. The particle size measurement by a dynamic light scattering device showed an average diameter of ∼200nm. The porosity measurement via the liquid displacement method showed that the scaffold could not meet the accepted ideal porosity percentage of above 80%, and the measured porosity percentage was ∼60%. The contact angle measurement displayed that the CGN coating made the scaffold highly hydrophilic with a zero degree contact angle. In vitro degradation study in the phosphate buffered saline revealed that the weight of the uncoated scaffold remained relatively constant. However, the CGNs-coated scaffold showed ∼45% weight-loss percentage after 40days. Cytocompati...Continue Reading

Citations

May 22, 2019·Pharmaceutical Development and Technology·Yue XuNan Zhang
Sep 8, 2017·The Journal of Physiological Sciences : JPS·Majid SalehiJafar Ai
Jan 16, 2020·Polymers·Angelika ZaszczynskaArkadiusz Gradys
Apr 11, 2019·Frontiers in Bioengineering and Biotechnology·Ryan J Hickey, Andrew E Pelling
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Dec 24, 2018·Journal of Biomedical Science·Rossana BoniAndrew N Clarkson
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Feb 5, 2021·International Journal of Biological Macromolecules·Madhavi Latha ChintaSreenivasa Rao Parcha
Nov 26, 2020·Emergent Materials·Ayca AydinCem Bulent Ustundag
Mar 7, 2021·Journal of Controlled Release : Official Journal of the Controlled Release Society·Parinaz AbdollahiyanAhad Mokhtarzadeh
Apr 7, 2021·Journal of Controlled Release : Official Journal of the Controlled Release Society·Parinaz AbdollahiyanAhad Mokhtarzadeh
Sep 18, 2021·Wiley Interdisciplinary Reviews. Nanomedicine and Nanobiotechnology·Lauren E Kass, Juliane Nguyen

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