Centella asiatica modulates antioxidant and mitochondrial pathways and improves cognitive function in mice

Journal of Ethnopharmacology
Nora E GrayAmala Soumyanath

Abstract

This study investigates the cognitive enhancing effects of the plant Centella asiatica which is widely used Ayurvedic and traditional Chinese medicine. The goal of this study was to determine the effects of a water extract of the medicinal plant Centella asiatica (CAW) on cognitive ability as well as mitochondrial and antioxidant response pathways in vivo. Old and young C57BL/6 mice were treated with CAW (2mg/mL) in their drinking water. Learning and memory was assessed using Morris Water Maze (MWM) and then tissue was collected and gene expression analyzed. CAW improved performance in the MWM in aged animals and had a modest effect on the performance of young animals. CAW also increased the expression of mitochondrial and antioxidant response genes in the brain and liver of both young and old animals. Expression of synaptic markers was also increased in the hippocampus and frontal cortex, but not in the cerebellum of CAW-treated animals. These data indicate a cognitive enhancing effect of CAW in healthy mice. The gene expression changes caused by CAW suggest a possible effect on mitochondrial biogenesis, which in conjunction with activation of antioxidant response genes could contribute to cognitive improvement.

References

May 14, 1996·Proceedings of the National Academy of Sciences of the United States of America·M J ForsterR S Sohal
Jun 1, 1997·Journal of the American Geriatrics Society·W J PerrigH B Stähelin
Jul 8, 1999·Current Opinion in Neurobiology·K M Harris
Jan 22, 2002·Journal of Ethnopharmacology·M H Veerendra Kumar, Y K Gupta
Jan 25, 2003·Pharmacology, Biochemistry, and Behavior·Y K GuptaA K Srivastava
Mar 20, 2004·Nature Reviews. Drug Discovery·Kevin J BarnhamAshley I Bush
Jul 20, 2005·Experimental Gerontology·Marimuthu SubathraChinnakkannu Panneerselvam
Dec 24, 2005·Nature Reviews. Neuroscience·Sara N Burke, Carol A Barnes
Jan 15, 2008·Journal of Ethnopharmacology·Jintanaporn WattanathornJintana Singkhoraard
Jun 2, 2011·International Journal of Alzheimer's Disease·Anil KumarSamrita Dogra
Nov 15, 2011·Recent Patents on Endocrine, Metabolic & Immune Drug Discovery·G K ShinomolMuchukunte M S Bharath
Dec 12, 2012·Neurological Sciences : Official Journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology·Atish Prakash, Anil Kumar
Feb 6, 2013·Ageing Research Reviews·Stephanie L Leal, Michael A Yassa

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Citations

May 16, 2018·Journal of Alzheimer's Disease : JAD·Joseph F Quinn
Feb 1, 2018·Phytochemistry Reviews : Proceedings of the Phytochemical Society of Europe·Nora E GrayAmala Soumyanath
Jun 26, 2020·Drug Metabolism and Disposition : the Biological Fate of Chemicals·Kirsten M WrightAmala Soumyanath
Oct 6, 2020·Frontiers in Pharmacology·Boju SunTonghua Liu
Sep 9, 2017·Oxidative Medicine and Cellular Longevity·Nora E GrayAmala Soumyanath
Mar 1, 2019·Turkish Journal of Biology = Türk Biyoloji Dergisi·Elly Ezlinda Abdul HisamMohd Zaki Salleh
Jul 7, 2019·International Journal of Molecular Sciences·Fiona LimanaqiFrancesco Fornai
Aug 13, 2020·Journal of Clinical Medicine·Rohit Sharma, Natália Martins
Jul 12, 2020·Journal of Alzheimer's Disease : JAD·Camila CalfioRicardo B Maccioni
Dec 11, 2019·Antioxidants·Donald G MatthewsAmala Soumyanath
Sep 6, 2019·Molecular Medicine Reports·Dimitris TsoukalasDaniela Calina
Dec 15, 2020·Neuroscience and Biobehavioral Reviews·Chiara MusilloFrancesca Cirulli
Dec 16, 2018·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Samaila Musa ChiromaMohamad Aris Mohd Moklas
Sep 5, 2021·BMC Complementary Medicine and Therapies·Supannikar TawinwungPhisit Khemawoot

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