Center-Level Experience and Kidney Transplant Outcomes in HIV-Infected Recipients

American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons
Jayme E LockeD L Segev

Abstract

Excellent outcomes among HIV+ kidney transplant (KT) recipients have been reported by the NIH consortium, but it is unclear if experience with HIV+ KT is required to achieve these outcomes. We studied associations between experience measures and outcomes in 499 HIV+ recipients (SRTR data 2004-2011). Experience measures examined included: (1) center-level participation in the NIH consortium; (2) KT experiential learning curve; and (3) transplant era (2004-2007 vs. 2008-2011). There was no difference in outcomes among centers early in their experience (first 5 HIV+ KT) compared to centers having performed >6 HIV+ KT (GS adjusted hazard ratio [aHR]: 1.05, 95% CI: 0.68-1.61, p = 0.82; PS aHR: 0.93; 95% CI: 0.56-1.53, p = 0.76), and participation in the NIH-study was not associated with any better outcomes (GS aHR: 1.08, 95% CI: 0.71-1.65, p = 0.71; PS aHR: 1.13; 95% CI: 0.68-1.89, p = 0.63). Transplant era was strongly associated with outcomes; HIV+ KTs performed in 2008-2011 had 38% lower risk of graft loss (aHR: 0.62; 95% CI: 0.42-0.92, p = 0.02) and 41% lower risk of death (aHR: 0.59; 95% CI: 0.39-0.90, p = 0.01) than that in 2004-2007. Outcomes after HIV+ KT have improved over time, but center-level experience or consortium par...Continue Reading

References

Dec 20, 1979·The New England Journal of Medicine·H S LuftA C Enthoven
Jul 21, 1999·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·S J SchurmanB A Warady
Apr 12, 2002·The New England Journal of Medicine·John D BirkmeyerDavid E Wennberg
Nov 7, 2002·JAMA : the Journal of the American Medical Association·Peter J PronovostTammy L Young
Jan 22, 2004·Proceedings of the National Academy of Sciences of the United States of America·David J GranvilleRoberta A Gottlieb
May 19, 2004·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·David A AxelrodRobert M Merion
Jan 25, 2005·Seminars in Dialysis·Lyn FinelliMatthew J Arduino
May 11, 2005·Kidney International·Eduard M ScholtenJohan W de Fijter
Apr 26, 2007·Annals of Surgery·John D BirkmeyerTherese A Stukel
Jun 25, 2008·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Karl Y BilimoriaClifford Y Ko
Jun 13, 2009·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·L TricotD Salmon-Céron
Mar 3, 2010·The Journal of Bone and Joint Surgery. American Volume·Christian OhmannMax Geraedts
Jul 14, 2010·European Journal of Surgical Oncology : the Journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology·G A GooikerM W J M Wouters
Nov 19, 2010·The New England Journal of Medicine·Peter G StockMichelle E Roland
Nov 23, 2010·Journal of the International Association of Physicians in AIDS Care : JIAPAC·William K AdihXiaohong Hu
Feb 18, 2011·The New England Journal of Medicine·Lode J Swinnen
Mar 29, 2011·The Annals of Thoracic Surgery·Thomas K VargheseCarlos A Pellegrini
May 4, 2011·Journal of General Internal Medicine·Raj PadwalMarcello Tonelli
Apr 5, 2012·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·J M MiroUNKNOWN Spanish OLT in HIV-Infected Patients Working Group investigators

❮ Previous
Next ❯

Citations

Jun 18, 2015·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·B J BoyarskyD L Segev
Mar 10, 2016·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·J F SuarezJ F Camargo
May 10, 2016·Transplant Infectious Disease : an Official Journal of the Transplantation Society·D H LeeA M Doyle
Jul 28, 2016·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·J HussonA Amoroso
Aug 10, 2016·Transplant Infectious Disease : an Official Journal of the Transplantation Society·A R VicariR C Manfro
Oct 26, 2016·Transplantation Reviews·Deirdre Sawinski
Jan 10, 2017·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·C N KottonD Kumar
Sep 19, 2017·Transplant Infectious Disease : an Official Journal of the Transplantation Society·Dong Heun LeeAlden Doyle
Aug 4, 2018·Clinical Transplantation·Sarah E Van Pilsum RasmussenChristine M Durand
Feb 19, 2019·Clinical Transplantation·Emily A BlumbergUNKNOWN American Society of Transplantation Infectious Diseases Community of Practice
Nov 18, 2015·Annals of Surgery·Brian J Boyarsky, Dorry L Segev
Jun 1, 2019·Current Transplantation Reports·Luckmini LiyanageChristine M Durand
Nov 22, 2019·AIDS Research and Therapy·Xin ZhengXiaopeng Hu
Dec 10, 2017·Clinical Transplantation·Ayla CashChristine M Durand
Jul 7, 2018·Current Treatment Options in Infectious Diseases·Ashton A Shaffer, Christine M Durand
Jan 21, 2021·World Journal of Surgery·Brian J BoyarskyDorry L Segev
May 31, 2019·Current Opinion in Organ Transplantation·Brian J BoyarskyChristine M Durand

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Transplant International : Official Journal of the European Society for Organ Transplantation
Colin R LenihanTara I Chang
American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons
J D Schold, B Kaplan
Journal of the American Society of Nephrology : JASN
Jayme E LockeD L Segev
American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons
A M CalinescuV A McLin
© 2021 Meta ULC. All rights reserved