Central 5-HT receptors and their function; present and future.

Neuropharmacology
Trevor Sharp, Nicholas M Barnes

Abstract

Since our review of central 5-HT receptors and their function twenty years ago, no new 5-HT receptor has been discovered and there is little evidence that this situation will change in the near future. Nevertheless, over this time significant progress has been made in our understanding of the properties of these receptors and in the clinical translation of this information, and some of these developments are highlighted herein. Such highlights include extensive mapping of 5-HT receptors in both animal and human brain, culminating in readily-accessible brain atlases of 5-HT receptor distribution, as well as emerging data on how 5-HT receptors are distributed within complex neural circuits. Also, a range of important pharmacological and genetic tools have been developed that allow selective 5-HT receptor manipulation, in cells through to whole organism models. Moreover, unexpected complexity in 5-HT receptor function has been identified including agonist-dependent signalling that goes beyond the pharmacology of canonical 5-HT receptor signalling pathways set down in the 1980s and 1990s. This new knowledge of 5-HT signalling has been extended by the discovery of combined signalling of 5-HT and co-released neurotransmitters, especi...Continue Reading

References

Dec 1, 1979·Naunyn-Schmiedeberg's Archives of Pharmacology·M Göthert, G Weinheimer
Mar 1, 1992·Pharmacology & Toxicology·B Costall, R J Naylor
Jan 1, 1992·Neuroscience and Biobehavioral Reviews·W KoekF C Colpaert
Aug 1, 1991·Trends in Pharmacological Sciences·A A Parsons
Nov 1, 1990·British Journal of Pharmacology·H H Berendsen, C L Broekkamp
Oct 1, 1990·British Journal of Pharmacology·H W Boddeke, H O Kalkman
Apr 1, 1995·Pharmacology & Therapeutics·S L Handley
Apr 15, 1993·Proceedings of the National Academy of Sciences of the United States of America·M G ErlanderK Cannon
Jun 1, 1993·Trends in Pharmacological Sciences·P P HumphreyD Hoyer
Oct 1, 1995·Pharmacopsychiatry·B OlivierR Hen
Apr 1, 1996·British Journal of Pharmacology·J Ge, N M Barnes
Feb 5, 1996·The Journal of Comparative Neurology·H K KiaD Vergé
Dec 1, 1996·Journal of the Neurological Sciences·R M ParkerN M Barnes
Sep 26, 1997·Naunyn-Schmiedeberg's Archives of Pharmacology·G W PriceD N Middlemiss
Dec 24, 1998·British Journal of Pharmacology·A Adell, F Artigas
Aug 26, 1999·Neuropharmacology·N M Barnes, T Sharp
May 24, 2000·British Journal of Pharmacology·J J HaganD R Thomas
Feb 6, 2003·European Journal of Pharmacology·Stephen P KelleyClyde W Hodge
Feb 18, 2003·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Gerard J MarekLawrence H Price
Sep 1, 1957·British Journal of Pharmacology and Chemotherapy·J H GADDUM, Z P PICARELLI
Jan 16, 2004·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Valérie CompanRené Hen
Feb 18, 2004·Current Drug Targets. CNS and Neurological Disorders·D L Nelson
Apr 14, 2004·The European Journal of Neuroscience·Amanda J RobertsPeter B Hedlund

❮ Previous
Next ❯

Citations

Feb 2, 2021·The FEBS Journal·Praachi TiwariVidita A Vaidya
Mar 7, 2021·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Sanung EomJunho H Lee
Apr 29, 2021·Journal of Neuroendocrinology·Teodora GeorgescuLora K Heisler
Aug 8, 2021·Journal of Clinical Medicine·Mónica GrosEva Latorre
Oct 3, 2020·Neuropharmacology·Giuseppe Di Giovanni, Philippe De Deurwaerdère
Dec 31, 2021·The Science of the Total Environment·Patricia I PintoD M Power

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Experimental and Clinical Endocrinology & Diabetes : Official Journal, German Society of Endocrinology [and] German Diabetes Association
L R CataldoJ L Santos
Biochimica Et Biophysica Acta
Derek A Mann, Fiona Oakley
© 2022 Meta ULC. All rights reserved