PMID: 6160823Oct 1, 1980Paper

Central action of intraventricularly-injected midodrine in rats

Archives Internationales De Pharmacodynamie Et De Thérapie
Z KleinrokA Oktaba-Polkowska

Abstract

The aim of the present paper was to investigate the effect of intracerebroventricular (i.v.c.) injections of midodrine on the central nervous system of the rat. It was shown that midodrine increased locomotor activity, decreased body temperature, increased sedation in reserpinized rats and the cataleptic effect of haloperidol. Midodrine enhanced amphetamine-stimulated locomotor activity and reduced the amphetamine and apomorphine sterotypy. Phenoxybenzamine, yohimbine and clonidine inhibited the midodrine-induced hyperactivity. Midodrine depressed the whole brain noradrenaline (NA) and dopamine (DA) concentrations and reduced NA turnover. The results suggest a stimulating action of midodrine on the catecholaminergic neurons.

Related Concepts

Related Feeds

Antipsychotic Drugs

Antipsychotic drugs are a class of medication primarily used to manage psychosis (including delusions, hallucinations, paranoia or disordered thought), principally in schizophrenia and bipolar disorder. Discover the latest research on antipsychotic drugs here

Related Papers

Acta Physiologica Polonica
E Jagiełło-Wójtowicz
Polish Journal of Pharmacology and Pharmacy
K Przesmycki, Z Kleinrok
Polish Journal of Pharmacology and Pharmacy
E Jagiełło-Wójtowicz
© 2021 Meta ULC. All rights reserved