Central activation, metabolites, and calcium handling during fatigue with repeated maximal isometric contractions in human muscle

European Journal of Applied Physiology
Simeon P CairnsMartin W Thompson

Abstract

To determine the roles of calcium (Ca2+) handling by sarcoplasmic reticulum (SR) and central activation impairment (i.e., central fatigue) during fatigue with repeated maximal voluntary isometric contractions (MVC) in human muscles. Contractile performance was assessed during 3 min of repeated MVCs (7-s contraction, 3-s rest, n = 17). In ten participants, in vitro SR Ca2+-handling, metabolites, and fibre-type composition were quantified in biopsy samples from quadriceps muscle, along with plasma venous [K+]. In 11 participants, central fatigue was compared using tetanic stimulation superimposed on MVC in quadriceps and adductor pollicis muscles. The decline of peak MVC force with fatigue was similar for both muscles. Fatigue resistance correlated directly with % type I fibre area in quadriceps (r = 0.77, P = 0.009). The maximal rate of ryanodine-induced Ca2+-release and Ca2+-uptake fell by 31 ± 26 and 28 ± 13%, respectively. The tetanic force depression was correlated with the combined reduction of ATP and PCr, and increase of lactate (r = 0.77, P = 0.009). Plasma venous [K+] increased from 4.0 ± 0.3 to 5.4 ± 0.8 mM over 1-3-min exercise. Central fatigue occurred during the early contractions in the quadriceps in 7 out of 17 pa...Continue Reading

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Citations

Jan 25, 2019·Journal of Sport Rehabilitation·Justin H Rigby, Austin M Hagan
Dec 7, 2019·Applied Physiology, Nutrition, and Metabolism = Physiologie Appliquée, Nutrition Et Métabolisme·Dustin J OranchukGuillaume Y Millet
Mar 21, 2019·Scandinavian Journal of Medicine & Science in Sports·Preeti D OzaRichard K Shields
Jul 12, 2019·Frontiers in Physiology·Benjamin J C KirkAnthony J Blazevich
Jan 5, 2021·European Journal of Applied Physiology·Michael I Lindinger, Simeon P Cairns

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Methods Mentioned

BETA
biopsy
force measurements

Software Mentioned

Labview
SPSS
Excel
Aminco Bowman

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