Central administration of melanin-concentrating hormone (MCH) suppresses food intake, but not locomotor activity, in the goldfish, Carassius auratus

Neuroscience Letters
K MatsudaAkiyoshi Takahashi

Abstract

Melanin-concentrating hormone (MCH) is a hypothalamo-pituitary peptide, which was first identified in the salmon pituitary as a hormone affecting body color. Recently, MCH has been implicated in the regulation of feeding behavior and energy homeostasis in mammals. Despite a growing body of knowledge concerning MCH in mammals, however, there is little information about the effect of MCH on appetite and behavior in fish. The aim of the present study was to investigate the action of MCH on feeding behavior and spontaneous locomotor activity in the goldfish. We administered synthetic MCH by intracerebroventricular (ICV) injection and examined its effect on food intake and locomotor activity using an automatic monitoring system. Both types of synthetic MCH we employed, which are of fish and human origin, were effective in stimulating aggregation of melanin granules in the melanophores of goldfish scales. Cumulative food intake was significantly decreased by ICV injection of both MCHs in a dose-dependent manner. ICV injection of fish MCH at the same doses as those used for examination of food intake induced no marked changes in locomotor activity during the observation period. These results suggest that MCH influences feeding behavio...Continue Reading

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Citations

Jan 18, 2007·Cell and Tissue Research·Kouhei MatsudaAkiyoshi Takahashi
Jan 23, 2016·Physiology & Behavior·Xian LiYing Liu
Oct 20, 2009·Peptides·Kouhei MatsudaAkiyoshi Takahashi
Oct 28, 2008·Comparative Biochemistry and Physiology. Part A, Molecular & Integrative Physiology·Kouhei MatsudaAkiyoshi Takahashi
Jul 1, 2015·Molecular and Cellular Endocrinology·Jin-Hyoung KimRobert H Devlin
Oct 2, 2008·Journal of Experimental Zoology. Part A, Ecological Genetics and Physiology·Takeshi YamanomeAkiyoshi Takahashi
May 22, 2009·Annals of the New York Academy of Sciences·Kouhei Matsuda
May 12, 2006·Peptides·Kouhei MatsudaSeiji Shioda
Jul 25, 2014·General and Comparative Endocrinology·Kanta MizusawaAkiyoshi Takahashi
Aug 16, 2014·Fish & Shellfish Immunology·Gino NardocciRicardo Fernández
Apr 12, 2014·Frontiers in Endocrinology·Md ShahjahanIshwar S Parhar
May 4, 2007·General and Comparative Endocrinology·Noriko AmiyaAkiyoshi Takahashi
Jul 13, 2020·Genome Biology and Evolution·Matthew L AardemaS Elizabeth Alter
May 2, 2017·Frontiers in Endocrinology·Ivar RønnestadHélène Volkoff
Sep 13, 2017·Fish Physiology and Biochemistry·Jin-Hyoung KimRobert H Devlin
Dec 19, 2019·Frontiers in Neuroscience·Giovanne B Diniz, Jackson C Bittencourt
Jun 6, 2019·Theriogenology·Azadeh Hatef, Suraj Unniappan

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