Central administration of PACAP stimulates gastric secretion mediated through the vagal pathway in anesthetized rats

Digestive Diseases and Sciences
M OzawaM Okuma

Abstract

Pituitary adenylate cyclase activating polypeptide (PACAP) is a neuropeptide that was originally isolated from ovine hypothalamic tissue. The peptide has two amidated forms, PACAP38 and PACAP27. In this study, we examined the effects of centrally administered PACAP38 and PACAP27 on gastric secretion in anesthetized rats. Centrally administered PACAP stimulated gastric acid and pepsin secretion in a dose-dependent manner. PACAP38 was 1.5-2 times more potent than PACAP27 on gastric secretion. By contrast, intravenously administered PACAP38 had no effect on basal or pentagastrin-stimulated gastric secretion. PACAP6-38, a PACAP antagonist, by itself at high doses also stimulated gastric and pepsin secretion, but at lower doses had no effect. Centrally administered PACAP6-38 at a dose that had no effect on gastric secretion, atropine pretreatment, or vagotomy pretreatment, suppressed the stimulatory effect of PACAP38. It is concluded that centrally administered PACAP may have a regulatory effect on gastric secretion through PACAP receptors and the vagal pathway.

Citations

Sep 15, 2001·American Journal of Physiology. Gastrointestinal and Liver Physiology·A K SandvikH L Waldum
Apr 20, 2006·Critical Reviews in Food Science and Nutrition·M N Satyanarayana
Oct 19, 2010·American Journal of Physiology. Heart and Circulatory Physiology·Melissa M J FarnhamPaul M Pilowsky

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