Central alpha-adrenergic agonists and need-induced 3% NaCl and water intake

Pharmacology, Biochemistry, and Behavior
M M YadaL A De Luca Júnior

Abstract

In the present study, noradrenaline (NOR, alpha-non-specific adrenergic agonist), clonidine (CLO, alpha 2), phenylephrine (PHE, alpha 1) or isoproterenol (ISO, beta-agonist) was injected in the medial septal area (MSA) of water-deprived, sodium-deplete or food-deprived rats. NOR (80, 160 nmol) inhibited the intake of 3% NaCl, water deprivation-induced and meal-associated water intake. Food deprivation-induced food intake and 10% sucrose intake were not altered by NOR. CLO (10, 20, 30, 40 nmol) inhibited (80-100% inhibition compared to control during 60 min) the intake of 3% NaCl, water deprivation-induced and meal-associated water intake. CLO had a weaker inhibition on food and 10% sucrose intake (30-50% less than the control during 60 and 15 min, respectively). PHE (160 nmol) inhibited 3% NaCl intake and 10% sucrose intake (30% less than the control for 15-30 min). ISO (160 nmol) did not alter water or 3% NaCl intake. NOR induced an increase, CLO and ISO induced a decrease, and PHE no alteration in mean arterial pressure. NOR did not alter water or 3% NaCl intake when injected unilaterally into the caudate nucleus. The results suggest that NOR injected in the MSA acts on alpha 2-adrenergic receptors inducing a specific inhibit...Continue Reading

References

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Jan 1, 1997·Brain Research Bulletin·M M YadaL A De Luca

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Citations

Dec 4, 2003·Brain Research·Lisandra Brandino de OliveiraJosé Vanderlei Menani
Oct 2, 2003·European Journal of Pharmacology·Shahrbanoo OryanBehrooz Kohanrooz
Nov 12, 2002·Brain Research·Lisandra Oliveira MargathoJosé Vanderlei Menani
Apr 20, 1999·Pharmacology, Biochemistry, and Behavior·L A De LucaE W Meyer
Jan 1, 1997·Brain Research Bulletin·M M YadaL A De Luca
Jul 29, 1999·Brain Research Bulletin·J V MenaniL A De Luca
Jul 5, 2008·Brain Research Bulletin·Débora Simões Almeida ColombariSergio Luiz Cravo
Apr 9, 2011·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·R L AlmeidaL A De Luca

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