PMID: 9423930Jan 10, 1998Paper

Central and peripheral actions of the NSAID ketoprofen on spinal cord nociceptive reflexes

Neuropharmacology
Juan F HerreroF Cervero

Abstract

Ketoprofen is a non-steroidal antiinflammatory drug (NSAID) which provides effective analgesia in situations of pain provoked by tissue inflammation. However, the location of its analgesic effects, (peripheral tissues versus central nervous system), have not been clearly identified and separated. In the present study the effectiveness of ketoprofen was examined in two different types of experiments: (i) Open field behavioural tests in conscious rats, and (ii) spinal cord nociceptive reflexes (single motor units) activated by electrical and thermal stimulation in chloralose anaesthetised rats. The experiments were performed in rats with carrageenan-induced inflammation of one hindpaw, or of one knee joint. The administration of ketoprofen significantly inhibited the reduction of exploratory movements caused by inflammation in open field experiments. Ketoprofen was also effective in depressing reflex activity evoked by electrical and noxious thermal stimulation of the skin, either in inflamed tissue or in normal tissue of monoarthritic animals. It was also effective in the reduction of reflex wind-up; a phenomenon in which the activity of spinal cord neurones increases progressively with high frequency electrical stimulation. We ...Continue Reading

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Citations

Jan 20, 2004·European Journal of Pharmacology·María Irene Díaz-RevalFrancisco Javier López-Muñoz
Feb 13, 1999·Progress in Neurobiology·M J Millan
Mar 8, 2000·Progress in Neurobiology·J F HerreroJ A López-García
Nov 5, 1999·Neuroscience Letters·J Mazario, J F Herrero
May 2, 2002·Paediatric Anaesthesia·Hannu KokkiAntti Jekunen
Jun 29, 2006·Clinical Pharmacokinetics·Anne MannilaJouko Savolainen
Dec 14, 1999·The European Journal of Neuroscience·A LevinssonJ Schouenborg
Mar 6, 2015·Revista brasileira de anestesiologia·Lanucha Fidelis da Luz MouraEmerson Antonio Contesini
Dec 13, 2006·European Journal of Pharmacology·Hai-Xia QiuXing-Guo Mei
Dec 7, 2006·Pain Practice : the Official Journal of World Institute of Pain·Pedro F Bejarano, Juan F Herrero
Feb 24, 2015·Neuroscience Letters·Coram GuevaraHeberto Suarez-Roca
Dec 18, 2001·Brazilian Journal of Medical and Biological Research = Revista Brasileira De Pesquisas Médicas E Biológicas·W A Prado, R M C Pontes
Mar 4, 2000·Anaesthesia and Intensive Care·A S RaoK Inbasegaran
Dec 1, 1998·Journal of Clinical Pharmacology·Francisco Javier López-MuñozDavid Mauleón

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