Central and peripheral airway/alveolar sites of exhaled nitric oxide in acute asthma

Thorax
Arthur F GelbTamara Maginot

Abstract

Central airway nitric oxide flux (J'(awNO)) and peripheral airway/alveolar nitric oxide concentration (C(ANO)) during asthma exacerbation has not been investigated after correction for axial NO back-diffusion. After measuring exhaled NO (fraction of exhaled nitric oxide (F(E)NO); ppb) at 50, 100, 150 and 200 ml/s, J'(awNO) (nl/s) and C(ANO) (ppb) were calculated using the two-compartment model and corrected for axial NO back-diffusion. Fifteen (8 males), non-smoking, patients with moderate-to-severe treated (inhaled corticosteroid (ICS) and inhaled long-acting beta(2)-agonist (LABA)) asthma, age 57+/-13 years (mean+/-SD), were studied at baseline, during exacerbation prior to oral corticosteroid, and during recovery after an 8 day tapering prednisone course. Based on earlier asthma studies without correction, it was hypothesised that with correction for NO axial back-diffusion, the incidence of abnormal J'(awNO) and C(ANO) at baseline and after exacerbation would be > or = 30% in 15 patients with asthma with 80% power. At baseline when clinically stable, after 180 microg of albuterol, forced expiratory volume in 1 s (FEV(1); litres) was 78+/-26% predicted (p=0.009) with increased F(E)NO at 50 ml/s (p=0.01) and J'(awNO) (p=0.02)...Continue Reading

Associated Clinical Trials

Citations

Jan 28, 2014·PloS One·Sandrah P EckelFrank D Gilliland
Aug 14, 2010·Chest·Arthur F GelbSreelakshmi Shakkottai
Apr 4, 2013·Annals of Allergy, Asthma & Immunology : Official Publication of the American College of Allergy, Asthma, & Immunology·Hitoshi NakajiMichiaki Mishima
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Jun 7, 2015·Respiratory Medicine·Mauro ManiscalcoAnna Zedda
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Feb 6, 2013·The Journal of Allergy and Clinical Immunology·Erica van der WielMaarten van den Berge
Sep 10, 2013·The Journal of Allergy and Clinical Immunology·Bruno Mahut, Christophe Delclaux
Aug 18, 2016·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·P MasonP Maestrelli
Oct 23, 2018·Scandinavian Journal of Clinical and Laboratory Investigation·Paul Guenther Lassmann-KleePäivi Piirilä
Jun 21, 2018·The Journal of Asthma : Official Journal of the Association for the Care of Asthma·Zsófia LázárAndrás Bikov
Jun 27, 2019·Journal of Breath Research·Tuomas Karvonen, Lauri Lehtimäki
Jun 6, 2019·The Journal of Asthma : Official Journal of the Association for the Care of Asthma·Takamitsu AsanoAkio Niimi

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