Central and peripheral cardiovascular actions of adrenomedullin 5, a novel member of the calcitonin gene-related peptide family, in mammals

The Journal of Endocrinology
Yoshio TakeiYoichi Ueta

Abstract

Adrenomedullin 5 (AM5) is a new member of the calcitonin gene-related peptide (CGRP) family identified in teleost fish. Although its presence was suggested in the genome database of mammals, molecular identity and biological function of AM5 have not been examined yet. In this study, we cloned a cDNA encoding AM5 in the pig and examined its cardiovascular and renal effects. Putative mature AM5 was localized in the middle of prohormone and had potential signals for intermolecular ring formation and C-terminal amidation. The AM5 gene was expressed most abundantly in the spleen and thymus. Several AM5 genes were newly identified in the database of mammals, which revealed that the AM5 gene exists in primates, carnivores, and undulates but could not be identified in rodents. In primates, nucleotide deletion occurred in the mature AM5 sequence in anthropoids (human and chimp) during transition from the rhesus monkey. Synthetic mature AM5 injected intravenously into rats induced dose-dependent decreases in arterial pressure at 0.1-1 nmol/kg without apparent changes in heart rate. The decrease was maximal in 1 min and AM5 was approximately half as potent as AM. AM5 did not cause significant changes in urine flow and urine Na+ concentrat...Continue Reading

Citations

Feb 22, 2014·Nature Communications·Shiroh IwanagaMasao Yuda
Oct 7, 2014·Comparative Biochemistry and Physiology. Part A, Molecular & Integrative Physiology·Melissa S CameronJohn A Donald
Jul 21, 2009·Comparative Biochemistry and Physiology. Part B, Biochemistry & Molecular Biology·Marty K S Wong, Yoshio Takei
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Oct 17, 2008·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Maho OgoshiYoshio Takei
May 3, 2008·General and Comparative Endocrinology·Yoshio Takei

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