Central and peripheral circulatory effects and metabolic effects of different prostaglandins given I.V. to man

Prostaglandins
B Eklund, L A Carlson

Abstract

Cardiac output, heart rate, stroke volume, pressures in the brachial artery, right ventricle and pulmonary artery, forearm blood flow, and arterial concentration of FFA, lactate and glucose were measured in healthy male volunteers during i-v infusion of PGE1, PGE2, PGF2 alpha or 15-methyl PGF2 alpha in increasing doses. In accordance with previous findings PGE1 and PGE2 increased cardiac output by a vasodilating effect in the systemic and pulmonary vascular bed, probably in combination with an inotropic effect on the heart. 15-methyl PGF2 alpha had essentially the same cardiovascular effects as PGF2 alpha. They induced a slight increase in cardiac output due to effects on heart rate, while systemic vascular resistance was unchanged. Forearm vascular resistance increased and pressures in the pulmonary circulation rose, indicating a vasoconstriction in these vascular beds. Glucose concentrations was not affected nor were lactate concentrations, except for a slight decrease of unclear significance in the group receiving 15-methyl PGF2 alpha. FFA increased slowly in the same manner as seen spontaneously in fasting individuals. These data do not indicate direct metabolic effects of the prostaglandins studied when given i-v.

References

Nov 1, 1976·Scandinavian Journal of Clinical and Laboratory Investigation·P E NielsenN A Lassen
Jul 1, 1971·Cardiovascular Research·S KarimK Hillier
Mar 17, 1972·Science·S BergströmM Bygdeman

Citations

Jan 1, 1983·European Journal of Clinical Pharmacology·N NaeijeR Sergijsels
Mar 1, 1983·Prostaglandins, Leukotrienes, and Medicine·H J Mest, J Rausch
Aug 1, 1983·Prostaglandins, Leukotrienes, and Medicine·W SziegoleitW Förster
Feb 4, 2009·Cephalalgia : an International Journal of Headache·T WieneckeM Ashina
Sep 26, 2012·Hypertension·Christina S BartlettRichard M Breyer
Aug 2, 2011·Prostaglandins & Other Lipid Mediators·Christina E Swan, Richard M Breyer
Jan 12, 2000·Journal of Toxicology. Clinical Toxicology·R MrvosE P Krenzelok
Mar 22, 2015·International Journal of Obstetric Anesthesia·J A AnsonP M McQuillan
Mar 1, 1983·Cephalalgia : an International Journal of Headache·S KaivolaH Timonen
Jul 1, 1995·The Journal of International Medical Research·T AonoK Hatakeyama
Sep 17, 2015·Advances in Nutrition·Melissa GabbsHarold M Aukema

Related Concepts

Blood Glucose
Diastolic Blood Pressure
Carboprost
Cardiac Output
Nonesterified Fatty Acids
Pulse Rate
Hemodynamics
Lactates
Prostaglandins E
Prostaglandins F

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