Central and peripheral contribution to the antihypertensive action of indoramin

European Journal of Pharmacology
T Baum, A T Shropshire

Abstract

Indoramin has been reported to reduce blood pressure in experimental animals and humans. The complex pharmacological profile of the compound suggests that it may also exert central actions. Effects on spontaneous sympathetic outflow and on sympathetic nerve and blood pressure responses to hypothalamic stimulation were examined in anesthetized cats in the present study. At a low dose (1 mg/kg) indoramin reduced blood pressure but did not significantly influence the level of efferent sympathetic nerve activity. A higher dose (5 mg/kg) lowered pressure further and inhibited activity in the splanchnic, cardiac and renal nerves indicating that reduced sympathetic outflow is a contributing factor to the hypotensive response at this dose. However, in contrast to other centrally acting antihypertensive agents, e.g., clonidine, indoramin did not inhibit the increase in sympathetic nerve activity produced by hypothalamic stimulation.

Citations

May 1, 1976·European Journal of Pharmacology·T Baum, A T Shropshire
Sep 1, 1977·European Journal of Pharmacology·J M Elliott, D W Clark
Nov 21, 1980·European Journal of Pharmacology·M A Davison, M C Koss
Nov 27, 1984·European Journal of Pharmacology·A G Ramage
Feb 12, 1985·European Journal of Pharmacology·J P PorterM J Brody
Feb 11, 1986·European Journal of Pharmacology·A G Ramage
Dec 13, 1988·European Journal of Pharmacology·T ItoM C Koss
Jul 3, 1990·European Journal of Pharmacology·M C KossT Ito
Mar 5, 1991·European Journal of Pharmacology·M C Koss
Sep 1, 1976·Neuropharmacology·T Baum, A T Shropshire
Feb 1, 1981·Journal of the Autonomic Nervous System·R B McCall, S J Humphrey
Feb 1, 1987·Journal of the American College of Cardiology·C V LeierD V Unverferth
Sep 13, 2013·Anti-cancer Drugs·Wen-Tai LiChiung-Tong Chen
Oct 5, 1984·The American Journal of Medicine·M J BrodyA J Trapani
Jun 1, 1984·British Journal of Clinical Pharmacology·D P NichollsR G Shanks
Jan 1, 1983·British Journal of Clinical Pharmacology·D P NichollsR G Shanks
Feb 1, 1986·British Journal of Pharmacology·V PierceJ F Waterfall

Related Concepts

Related Feeds

Antihypertensive Agents: Mechanisms of Action

Antihypertensive drugs are used to treat hypertension (high blood pressure) which aims to prevent the complications of high blood pressure, such as stroke and myocardial infarction. Discover the latest research on antihypertensive drugs and their mechanism of action here.

Cardiac Conduction System

The cardiac conduction system is a specialized tract of myocardial cells responsible for maintaining normal cardiac rhythm. Discover the latest research on the cardiac conduction system here.