Central and peripheral corneal thinning in keratoconus

Cornea
Rune L BrautasetJan P G Bergmanson

Abstract

Recent data regarding the mid-peripheral portion of the removed corneal button in transplant surgery indicate histopathologically that keratoconus was present also in the peripheral portion of the button. The intent of this study was therefore to investigate if peripheral changes could also be detected clinically by measuring the central and peripheral corneal thickness of KC patients. Corneal pachymetry was measured with the Visante optical coherence tomography and Orbscan II. Of 52 subjects, 26 were KC subjects and 26 were age- and sex-matched control subjects. Corneal thickness, in KC patients, was significantly reduced in all areas compared with corneal thickness among controls with both the Visante optical coherence tomography and Orbscan II. The results of the present study have provided clinical evidence that KC is a disease affecting a wider area of the cornea. Although the KC cornea shows the greatest change in thickness in the ectatic region, this attenuation declines toward the periphery. The presence of peripheral thinning indicated that KC may be a "pancorneal" pathology and not limited to the ectatic portion.

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Citations

Mar 26, 2013·Journal of AAPOS : the Official Publication of the American Association for Pediatric Ophthalmology and Strabismus·Lokman AslanGökhan Özdemir
Aug 19, 2015·Acta Ophthalmologica·Jessica H MathewJan P G Bergmanson
Apr 9, 2015·Contact Lens & Anterior Eye : the Journal of the British Contact Lens Association·M NilssonR L Brautaset
Jun 1, 2013·Current Eye Research·Metin EkinciGokcen Gokce
May 4, 2015·Journal of Cataract and Refractive Surgery·Bettina SchlatterMartin Zinkernagel
Mar 25, 2018·Ophthalmic & Physiological Optics : the Journal of the British College of Ophthalmic Opticians (Optometrists)·Hassan HashemiMehdi Khabazkhoob
Jan 6, 2018·Cornea·Necip KaraKıvanc Gungor
Sep 8, 2017·Clinical & Experimental Optometry : Journal of the Australian Optometrical Association·Mohammad NaderanMahgol Farjadnia
Apr 19, 2017·The British Journal of Ophthalmology·Aljoharah AlkanaanSaeed Akhtar
Jan 6, 2017·Journal of Biomedical Optics·Manmohan SinghMichael D Twa
Mar 3, 2017·BioMed Research International·Mariam Lotfy KhaledYutao Liu
Jul 30, 2019·Cornea·Andrius BojarunRolandas Zablockis
Dec 11, 2017·Journal of Cataract and Refractive Surgery·Ramón Ruiz-MesaMaría Ruiz-Santos
Mar 30, 2021·Contact Lens & Anterior Eye : the Journal of the British Contact Lens Association·Laura E DownieJames S Wolffsohn
Jun 18, 2019·Journal français d'ophtalmologie·G HayekJ-M Perone
Jun 9, 2021·Contact Lens & Anterior Eye : the Journal of the British Contact Lens Association·Jan P G BergmansonShehzad A Naroo

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