Central and peripheral effects of thyroid hormone signalling in the control of energy metabolism

Journal of Neuroendocrinology
A Alkemade

Abstract

Increasing evidence points towards a role for thyroid hormone signalling in the central nervous system with respect to the development of symptoms of thyroid disease, in addition to the well-known peripheral effects of thyroid hormone. Thyroid hormone affects target tissues directly via thyroid hormone receptors, but also indirectly through effects on the integration of the sympathetic signal in target tissues. The present review discusses these pathways and the evidence for a third pathway, that is effects of thyroid hormone on the pre-autonomic neurones in the central nervous system. The pre-autonomic neurones reside in the hypothalamus in brain nuclei such as the paraventricular nucleus of the hypothalamus where thyroid hormone receptor isoforms are expressed. Recent data from studies in transgenic mice implicate a role for thyroid hormone receptor alpha 1 in the modulation of sympathetic signalling to target tissues, thereby affecting both glucose and lipid metabolism. Focal stimulation of hypothalamic nuclei expressing thyroid hormone receptors and selective liver denervation experiments in rats have provided further evidence indicating that the metabolic changes observed during hyperthyroidism are not only a result of inc...Continue Reading

References

Feb 1, 1992·Endocrinology·C B CookR J Koenig
Jun 1, 1993·Endocrine Reviews·S RefetoffS J Usala
Apr 1, 1993·The American Journal of Medicine·M T McDermott, E C Ridgway
Nov 9, 2000·Proceedings of the National Academy of Sciences of the United States of America·M KaneshigeS Cheng
Nov 14, 2001·Reviews in Endocrine & Metabolic Disorders·R E Weiss, S Refetoff
Dec 6, 2001·Proceedings of the National Academy of Sciences of the United States of America·M KaneshigeS Cheng
Jul 30, 2002·Molecular Endocrinology·Hjalmar GullbergBjörn Vennström
Aug 8, 2002·Thyroid : Official Journal of the American Thyroid Association·W H Dillmann
Oct 3, 2002·The EMBO Journal·Alexander TinnikovBjörn Vennström
Nov 25, 2004·The Journal of Clinical Endocrinology and Metabolism·Anneke AlkemadeEric Fliers
Apr 21, 2005·The Journal of Clinical Endocrinology and Metabolism·Anneke AlkemadeEric Fliers
Aug 30, 2005·The Journal of Clinical Investigation·Ana Luiza MaiaP Reed Larsen
Feb 25, 2006·European Journal of Endocrinology·Anneke AlkemadeEric Fliers
Jan 16, 2007·Molecular and Cellular Biology·Hao YingSheue-Yann Cheng
Aug 23, 2007·Nature Clinical Practice. Endocrinology & Metabolism·Ana Luiza Maia
Jan 10, 2008·American Journal of Physiology. Endocrinology and Metabolism·Lars P KlieverikEric Fliers
Feb 19, 2008·Thyroid : Official Journal of the American Thyroid Association·J Enrique Silva, Suzy D C Bianco
Feb 23, 2008·Trends in Endocrinology and Metabolism : TEM·W Edward VisserTheo J Visser
Mar 19, 2009·The Journal of Clinical Endocrinology and Metabolism·Karen A HeemstraTheo J Visser
Mar 27, 2009·Proceedings of the National Academy of Sciences of the United States of America·Lars P KlieverikAndries Kalsbeek
Apr 10, 2009·The New England Journal of Medicine·Kirsi A VirtanenPirjo Nuutila

❮ Previous
Next ❯

Citations

Jan 28, 2012·Journal of Huazhong University of Science and Technology. Medical Sciences = Hua Zhong Ke Ji Da Xue Xue Bao. Yi Xue Ying De Wen Ban = Huazhong Keji Daxue Xuebao. Yixue Yingdewen Ban·Jiaoyue ZhangTing Chen
Nov 24, 2012·Nutrition Research Reviews·Andoni LanchaJavier Gómez-Ambrosi
Oct 12, 2010·International Journal of Obesity : Journal of the International Association for the Study of Obesity·M Rosenbaum, R L Leibel
Nov 9, 2011·Proceedings of the National Academy of Sciences of the United States of America·Olga Barca-MayoRoy E Weiss
Apr 16, 2014·International Journal of Obesity : Journal of the International Association for the Study of Obesity·T XiaF Guo
Jun 14, 2018·Physiological Reviews·Benjamin Jurek, Inga D Neumann
Jun 20, 2018·American Journal of Physiology. Endocrinology and Metabolism·Michael RosenbaumRudolph L Leibel
Oct 16, 2010·Nanotechnology·Ping ChenPaul F A Alkemade
May 23, 2013·Endocrine Reviews·J BowersB A Demeneix
Jul 13, 2018·International Journal of Molecular Sciences·Soumaya Kouidhi, Marie-Stéphanie Clerget-Froidevaux
Aug 9, 2020·Diabetes, Metabolic Syndrome and Obesity : Targets and Therapy·Ken QinSheyu Li

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.