Central and peripheral fatigue: exemplified by multiple sclerosis and myasthenia gravis

PM & R : the Journal of Injury, Function, and Rehabilitation
Fredric Cantor

Abstract

Fatigue is a feature of several chronic diseases of the central and peripheral nervous system. The pathophysiology of central fatigue is complex and often not well-defined. In contrast, peripheral fatigue is more objectively defined and measured. Fatigue can be part of the primary disease process, but there are often contributions from comorbid factors such as depression, sleep disturbance, medication, or deconditioning. Multiple sclerosis (MS) offers an example of central fatigue. More than 40% of MS patients complain of fatigue. Validated questionnaires are used to assess fatigue severity and comorbid factors. Although fatigue is believed to be a primary process in MS, depression and sleep disturbance are often comorbid problems. Magnetic resonance imaging (MRI), positron emission tomography, and functional MRI studies suggest that fatigue is related to gray matter disease, particularly of the cerebral cortex, but also of the thalamus and caudate. Disruption of impulse propagation from demyelination is also a likely factor. It is uncertain if pro-inflammatory cytokines have a specific effect on the genesis of MS fatigue. Several medications have been reported to alleviate fatigue in MS, but controlled studies show contradicto...Continue Reading

References

Jan 1, 1987·Annals of the New York Academy of Sciences·D B Sanders
Jan 1, 1972·Zeitschrift Für Krebsforschung Und Klinische Onkologie. Cancer Research and Clinical Oncology·R J Lukes
Feb 1, 1995·Journal of the American Geriatrics Society·R G Logsdon, L Teri
Apr 3, 1998·Journal of Clinical and Experimental Neuropsychology·H Wishart, D Sharpe
Aug 28, 1998·Journal of Psychosomatic Research·H FordM Johnson
Oct 22, 1998·Journal of Neuroimaging : Official Journal of the American Society of Neuroimaging·R BakshiW R Kinkel
Sep 17, 1999·Neurology·S R SchwidA D Goodman
Jan 18, 2002·Journal of Neurology, Neurosurgery, and Psychiatry·K W RammohanH N Nagaraja
Apr 16, 2003·Annals of Medicine·Hymie Anisman, Zul Merali
Jun 20, 2003·Multiple Sclerosis : Clinical and Laboratory Research·Rohit Bakshi
Oct 30, 2003·Multiple Sclerosis : Clinical and Laboratory Research·Steven R SchwidMichael P McDermott
May 6, 2004·Multiple Sclerosis : Clinical and Laboratory Research·Peter FlacheneckerPeter Rieckmann
Oct 7, 2004·Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology·A M HummK M Rösler
Jan 28, 2005·The Cochrane Database of Systematic Reviews·M B RietbergG Kwakkel
Feb 8, 2005·Journal of the Neurological Sciences·Ruth Ann MarrieRichard A Rudick
Feb 16, 2005·Archives of Neurology·Michaela GottschalkFrank Weber
Mar 4, 2005·Current Neurology and Neuroscience Reports·Jay H Rosenberg, Renata Shafor
Mar 31, 2005·Seminars in Neurology·W Elon Fleming, Charles P Pollak
Apr 13, 2005·Neurology·Steven R Schwid, T Jock Murray
Apr 13, 2005·Neurology·B StankoffUNKNOWN French Modafinil Study Group
May 17, 2005·Archives of Clinical Neuropsychology : the Official Journal of the National Academy of Neuropsychologists·Lauren B Strober, Peter A Arnett
Dec 20, 2005·Journal of Neurology, Neurosurgery, and Psychiatry·G Giovannoni
Dec 20, 2005·Journal of Neurology, Neurosurgery, and Psychiatry·C HeesenS M Gold
Feb 14, 2006·Pharmacology & Therapeutics·Susan I V Judge, Christopher T Bever
Jun 13, 2006·Multiple Sclerosis : Clinical and Laboratory Research·C LebrunM Chatel
May 16, 2007·Journal of Neurology·Brigitte GreimUwe K Zettl
May 16, 2007·Journal of Neurology·Brigitte GreimUwe K Zettl
Jan 15, 2008·European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies·M KhademiE Wallström
Feb 7, 2008·The Cochrane Database of Systematic Reviews·A CicconeC Spreafico
Mar 5, 2008·International Journal of Nursing Practice·David LeeAnnie Topping
Mar 21, 2008·European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies·M C TartagliaD L Arnold
Jun 21, 2008·Multiple Sclerosis : Clinical and Laboratory Research·M O MelconUNKNOWN Patagonia Multiple Sclerosis Research Project

❮ Previous
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Citations

Jan 1, 2011·ISRN Neurology·Andrew W Barritt, David G Smithard
Nov 13, 2012·Journal of the Neurological Sciences·W K TangK S Wong
Aug 26, 2014·Clinical Linguistics & Phonetics·Matthew J MakashayNancy Pearl Solomon
Sep 1, 2012·Journal of the Neurological Sciences·Isuru InduruwaBruno Gran
Oct 27, 2012·Neurologic Clinics·Alex Moszczynski, Brian James Murray
Jul 31, 2012·Progress in Neurobiology·Mary E Harrington
Jul 27, 2010·PM & R : the Journal of Injury, Function, and Rehabilitation·Lynn H Gerber
Jul 27, 2010·PM & R : the Journal of Injury, Function, and Rehabilitation·Leonard A JasonNicole Porter
Jul 27, 2010·PM & R : the Journal of Injury, Function, and Rehabilitation·Eleanor SmithDavid Cella
May 25, 2015·Journal of the Neurological Sciences·Agathe BridouxJean-Pascal Lefaucheur
Feb 25, 2015·Tidsskrift for den Norske lægeforening : tidsskrift for praktisk medicin, ny række·Andreas Schillinger, Frank Becker
Feb 7, 2014·Practical Neurology·Yara Dadalti FragosoMonica Fiuza Koncke Parolin
Sep 25, 2016·Current Neurology and Neuroscience Reports·Kevin G BurfeindDaniel L Marks
Aug 10, 2018·Acta Neurologica Scandinavica·Annette BaumgartnerPhilipp T Meyer
Oct 14, 2017·Nature Reviews. Neurology·Iris-Katharina Penner, Friedemann Paul
May 23, 2015·The Anatomical Record : Advances in Integrative Anatomy and Evolutionary Biology·Bettina M Kreissl LonfatFrank Rühli
Jan 19, 2018·Folia Phoniatrica Et Logopaedica : Official Organ of the International Association of Logopedics and Phoniatrics (IALP)·Ellika SchallingLena Hartelius
Aug 9, 2019·World Journal of Gastroenterology : WJG·Lynn H GerberZobair M Younossi
Mar 20, 2021·Journal of Child Neurology·Giuseppina PilloniLeigh Charvet

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