PMID: 2497488Jan 1, 1989Paper

Central and peripheral muscarinic actions of physostigmine and oxotremorine on avoidance responding of squirrel monkeys

Psychopharmacology
J M Witkin

Abstract

The involvement of central and peripheral muscarinic cholinergic receptors in the behavioral effects of the cholinesterase inhibitor physostigmine was evaluated by comparing the ability of atropine and methylatropine to reverse the effects of physostigmine, the muscarinic agonist oxotremorine, or their quaternary analogs neostigmine and oxotremorine-M. Avoidance behavior was maintained under a schedule in which every lever press postponed delivery of electric shock for 20 s; shock occurred every 5 s in the absence of responding. Cumulative doses of physostigmine or oxotremorine produced dose-related decreases in response rates, and increases in response durations and rates of shock delivery. Similar effects occurred with neostigmine and oxotremorine-M. Methylatropine completely prevented the behavioral and parasympathetic effects of neostigmine and oxotremorine-M without having any behavioral effects of its own. However, methylatropine did not alter the behavioral effects of physostigmine or oxotremorine. Atropine prevented the peripheral manifestations as well as the behavioral effects of physostigmine and oxotremorine even though atropine decreased avoidance responding when given alone. These results suggest that in squirrel ...Continue Reading

References

Jun 1, 1978·The Journal of Pharmacy and Pharmacology·D E Burleigh
Jan 1, 1989·Pharmacology, Biochemistry, and Behavior·J M WitkinJ E Barrett
Jul 6, 1964·Psychopharmacologia·R K Chalmers, C K Erickson
Sep 1, 1973·Neuropharmacology·A WitterG K Terpstra
Mar 1, 1968·International Journal of Neuropharmacology·J A RosecransE F Domino
Jan 14, 1965·Psychopharmacologia·M E GoldbergJ B Knaak
Jan 1, 1966·British Journal of Pharmacology and Chemotherapy·A BebbingtonD Shakeshaft
May 1, 1966·British Journal of Pharmacology and Chemotherapy·R CabreraH Viveros
May 23, 1983·Life Sciences·B Ringdahl, D J Jenden
Mar 14, 1957·Annals of the New York Academy of Sciences·C C PFEIFFER, E H JENNEY
Jan 1, 1961·Recent Advances in Biological Psychiatry·M H APRISON
Apr 1, 1963·Journal of the Experimental Analysis of Behavior·D F HAKE, N H AZRIN
Oct 1, 1963·The American Journal of Physiology·P STARK, E S BOYD
Jul 20, 1964·Naunyn-Schmiedebergs Archiv für experimentelle Pathologie und Pharmakologie·G E VAILLANT
Jul 1, 1965·International Journal of Neuropharmacology·A HERZH KURZ

❮ Previous
Next ❯

Citations

Jan 1, 1989·Pharmacology, Biochemistry, and Behavior·J M WitkinJ E Barrett
Jan 1, 1992·Journal of American College Health : J of ACH·D BensonF Goodhart
Jan 11, 2020·Behavioural Pharmacology·Gail WingerJames H Woods

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.