Central and peripheral pulse wave velocity and subclinical myocardial stress and damage in older adults

PloS One
Shuiqing LiuKunihiro Matsushita

Abstract

Arterial stiffness independently predicts cardiovascular disease. However, few studies have evaluated the associations of central and peripheral pulse wave velocity (PWV) with biomarkers of both myocardial stress (natriuretic peptide [NT-proBNP]) and damage (high-sensitivity cardiac troponin-T [hs-cTnT]) among persons without cardiac disease. We examined 3,348 participants (67-90 years) without prevalent cardiac disease in the Atherosclerosis Risk in Communities (ARIC) Study (2011-13). The cross-sectional associations of PWV quartiles for central arterial segments (carotid-femoral, heart-carotid, heart-femoral) and peripheral artery (femoral-ankle) with NT-proBNP and hs-cTnT were evaluated accounting for potential confounders. Most PWV measures demonstrated J- or U-shaped associations with the two cardiac biomarkers. The highest (Q4) vs. second lowest (Q2) quartile of central PWV measures (carotid-femoral, heart-carotid, heart-femoral PWV) were associated with higher levels of NT-proBNP independently of demographic characteristics. The associations were less evident for hs-cTnT. These associations were attenuated after adjusting for traditional cardiovascular risk factors, but the heart-carotid PWV-NT-proBNP relationship remain...Continue Reading

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Citations

Jul 31, 2019·International Journal of Molecular Sciences·Takayuki NambaTakeshi Adachi
Feb 9, 2021·Frontiers in Cardiovascular Medicine·Keeron StoneLee Stoner
May 22, 2021·BMC Cardiovascular Disorders·Zakaria AlmuwaqqatAlvaro Alonso

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