PMID: 9529168Apr 7, 1998Paper

Central and regional hemodynamics during crystalloid fluid therapy after uncontrolled intra-abdominal bleeding

The Journal of Trauma
L RiddezR G Hahn

Abstract

To study the effect of graded crystalloid fluid resuscitation on central hemodynamics and outcome after intra-abdominal hemorrhage. Ten minutes after a 5-mm long laceration was produced in the infrarenal aorta, 32 pigs were randomized to receive either no fluid or Ringer's solution in the proportion 1:1, 2:1, or 3:1 to the expected amount of blood lost per hour (26 mL kg[-1]) over 2 hours. The hemodynamics were studied using arterial and pulmonary artery catheters and four blood flow probes placed over major blood vessels. During the first 40 minutes after the injury, the respective blood flow rates in the distal aorta were 39% (no fluid), 41% (1:1), 56% (2:1), and 56% (3:1) of the baseline flow. Fluid resuscitation increased cardiac output but had no effect on arterial pressure, oxygen consumption, pH, or base excess. Rebleeding occurred only with the 2:1 and 3:1 fluid programs. Survival was highest with the 1:1 and 2:1 programs. Crystalloid fluid therapy improved the hemodynamic status but increased the risk of rebleeding. Therefore, a moderate fluid program offered the best chance of survival.

References

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Citations

May 15, 2013·Therapeutic Hypothermia and Temperature Management·Göran HeiniusRobert G Hahn
Mar 18, 2008·Journal of Infusion Nursing : the Official Publication of the Infusion Nurses Society·Lynn Schweer
Sep 23, 2003·The Journal of Trauma·James MapstonePhillip Evans
Dec 24, 2005·The Journal of Trauma·Dan DrobinRobert G Hahn
Nov 19, 2005·The Journal of Trauma·Stephanie A SavageJeffrey D Kerby
Nov 8, 2002·Emergency Medicine Journal : EMJ·M RevellI Greaves
Dec 19, 2012·Journal of Emergencies, Trauma, and Shock·Fabrizio Giuseppe Bonanno
Jun 3, 2011·Journal of Emergencies, Trauma, and Shock·Paramjit KaurRavneet Kaur
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May 29, 1999·AACN Clinical Issues·W J Robb
Jul 12, 2007·International Anesthesiology Clinics·Sean K KaneAndrew D Friedrich
Sep 11, 2009·Current Opinion in Critical Care·Chitra N Sambasivan, Martin A Schreiber
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Aug 28, 2010·Critical Care Medicine·Yvette FoucheRichard P Dutton
Jan 9, 2014·The Journal of Surgical Research·Michael J DugganDavid R King
Jan 23, 2016·Seminars in Perinatology·Adiel Fleischer, Natalie Meirowitz
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Jun 11, 2002·International Anesthesiology Clinics·Richard P Dutton

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