Central angiotensin AT1-receptor blockade affects thermoregulation and running performance in rats

American Journal of Physiology. Regulatory, Integrative and Comparative Physiology
Laura H R LeiteCândido Celso Coimbra

Abstract

The effect of central angiotensin AT1-receptor blockade on thermoregulation in rats during exercise on a treadmill (18 m/min, 5% inclination) was investigated. Core (Tb) and skin tail temperatures were measured in rats while they were exercising until fatigue after injection of 2 microl of losartan (Los; 20 nmol, n = 4; 30 nmol, n = 4; 60 nmol, n = 7), an angiotensin II AT1-receptor antagonist, or 2 microl of 0.15 mol/l NaCl (Sal; n = 15) into the right lateral cerebral ventricle. Body heat rate (BHR), heat storage rate, threshold Tb for tail vasodilation (TTbV), time to fatigue, and workload were calculated. During exercise, the BHR and heat storage rate of Los-treated animals were, respectively, 40 and 53% higher (P < 0.01) than in Sal-treated animals. Additionally, rats injected with Los showed an increased TTbV (38.59 +/- 0.19 degrees C for Los vs. 38.12 +/- 0.1 degrees C for Sal, P < 0.02), a higher Tb at fatigue point (39.07 +/- 0.14 degrees C Los vs. 38.66 +/- 0.07 degrees C Sal, P < 0.01), and a reduced running performance (27.29 +/- 4.48 min Los vs. 52.47 +/- 6.67 min Sal, P < 0.01), which was closely related to the increased BHR. Our data suggest that AT1-receptor blockade attenuates heat dissipation during exercise d...Continue Reading

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Citations

May 24, 2012·Experimental Biology and Medicine·Laura H R LeiteKaushik P Patel
Oct 18, 2015·Clinical and Experimental Pharmacology & Physiology·Henrique P SantiagoCândido C Coimbra
May 27, 2016·Temperature : Multidisciplinary Biomedical Journal·Samuel Penna WannerFrancisco Teixeira-Coelho
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Feb 7, 2007·Neuroscience Letters·Danusa Dias SoaresUmeko Marubayashi
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Apr 17, 2008·Physiology & Behavior·A G RodriguesU Marubayashi
Jan 14, 2010·Medicine and Science in Sports and Exercise·Laura H R LeiteCândido C Coimbra
Sep 30, 2006·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Andrej A Romanovsky
Apr 3, 2010·Pharmacological Reports : PR·Cláudio H BalthazarCândido C Coimbra
Apr 17, 2009·Neuroreport·Alex G RodriguesCândido Celso Coimbra
Oct 17, 2015·Journal of Applied Physiology·Yeonjoo YooDmitry V Zaretsky

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