Central beta-adrenergic effects on the control of ventilation in cats

Respiration; International Review of Thoracic Diseases
H Folgering

Abstract

beta-Adrenergic mimetics and blockers, as well as a local anesthetic (xylocaine) were infused into the vertebral artery of paralyzed and artificially ventilated cats. The effects of the drugs on the central control of ventilation was assessed by measuring the changes in phrenic nerve activity. beta-Mimetics [isoprenaline (1 and 2), metroprolol (1), oxprenolol (1 and 2)] decreased the phrenic nerve activity. beta 2-Mimetics (Salbutamol) and blockers (Butoxamine, H 35/35) had no clear effects. The mode of action of the beta-blockers is most probably not by their local anesthetic properties. It is concluded that beta-adrenergic mechanisms in the brain stem stimulate the ventilatory control system. The receptors are most probably beta 1-receptors.

Citations

Jan 1, 1992·Journal of Tongji Medical University = Tong Ji Yi Ke Da Xue Xue Bao·Z Y LiC J Huang
Nov 1, 1995·Journal of Psychosomatic Research·L L Van De VenM J Hoes
Apr 1, 1986·Annals of Surgery·C WeissmanJ M Kinney
Aug 1, 1987·British Journal of Clinical Pharmacology·S B PearsonF G Simpson
Oct 1, 1981·Pflügers Archiv : European journal of physiology·H Folgering
Nov 1, 1983·The American Journal of Physiology·L SjöströmE Jéquier

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