Central Blood Pressure and Cardiovascular Outcomes in Chronic Kidney Disease

Clinical Journal of the American Society of Nephrology : CJASN
Mahboob RahmanCRIC Study Investigators

Abstract

Central BP measurements provide noninvasive measurement of aortic BP; our objectives were to examine the association of central and brachial BP measurements with risk of cardiovascular outcomes and mortality in patients with CKD and to determine the role of central BP measurement in conjunction with brachial BP in estimating cardiovascular risk. In a prospective, longitudinal study (the Chronic Renal Insufficiency Cohort), central BP was measured in participants with CKD using the SphygmoCorPVx System. Cox proportional hazards models were used for analyses. Mean age of the participants (n=2875) was 60 years old. After a median follow-up of 5.5 years, participants in the highest quartile of brachial systolic BP (≥138 mm Hg) were at higher risk for the composite cardiovascular outcome (hazard ratio, 1.59; 95% confidence interval, 1.17 to 2.17; c statistic, 0.76) but not all-cause mortality (hazard ratio, 1.28; 95% confidence interval, 0.90 to 1.80) compared with those in the lowest quartile. Participants in the highest quartile of central systolic BP were also at higher risk for the composite cardiovascular outcome (hazard ratio, 1.69; 95% confidence interval, 1.24 to 2.31; c statistic, 0.76) compared with participants in the low...Continue Reading

References

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Citations

May 19, 2018·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Vasiliki KaravaGeorges Deschênes
Apr 17, 2019·Current Hypertension Reviews·Anila DuniVassilios Liakopoulos
Feb 20, 2019·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Shweta ShahPoyyapakkam R Srivaths
Sep 26, 2020·Journal of the American Society of Nephrology : JASN·Mahboob RahmanUNKNOWN CRIC Study Investigators
Jul 31, 2019·Kidney & Blood Pressure Research·Rasmus Kirkeskov CarlsenNiels Henrik Buus

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