Central blood volume in spontaneously hypertensive rats and Wistar-Kyoto normotensive rats

Acta Physiologica Scandinavica
S LundinB Rippe

Abstract

Central blood volume and blood volume were determined in spontaneously hypertensive rats and Wistar Kyoto rats at two ages, 6 and 12 weeks, representing "borderline' hypertension and early "established' hypertension, respectively. A technique was used where plasma and erythrocyte indicators were injected into conscious rats. Blood volume in the cardiopulmonary compartment, present in the 'resting' awake steady-state, could then be estimated by sudden freezing of the entire rat. 12 week-old spontaneously hypertensive rats showed a decreased total blood volume, while the fraction of blood contained in the cardiopulmonary area was significantly increased compared with that of normotensive Wistar Kyoto rats. In 6-week-old spontaneously hypertensive rats, total blood volume was only marginally decreased but also here a tendency towards centralization of the blood was seen. Thus, alone with the development of hypertension in the spontaneously hypertensive rat their decreasing blood volume tends to become increasingly centralized to the cardiopulmonary area. Both neurohormonal influences and structural wall changes in the low-pressure capacitance side may contribute to this.

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Citations

Jul 12, 2007·Intensive Care Medicine·Maris DubniksPer-Olof Grände
Jul 1, 1992·Acta Anaesthesiologica Scandinavica·E Haglind, H Haljamäe
Jun 1, 1982·Acta Physiologica Scandinavica·P Virkkunen
May 1, 1983·Acta Physiologica Scandinavica·S LundinS E Ricksten
Sep 1, 1985·Acta Physiologica Scandinavica·P FribergM Nordlander
Jun 26, 1982·Lancet·H E de Wardener, G A MacGregor
Dec 1, 2011·Cellular and Molecular Bioengineering·Cécile PotGeert W Schmid-Schönbein
Jan 1, 1983·Clinical and Experimental Hypertension. Part A, Theory and Practice·R T EvenwelH A Struyker-Boudier
Sep 13, 2011·Microvascular Research·Peter BanschPeter Bentzer
Dec 1, 1991·Blood Reviews·T C Pearson

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