PMID: 3755956Jul 1, 1986Paper

Central Ca++-channel blockade reverses ethanol-induced poikilothermia in the rat

Alcohol
A H RezvaniR D Myers

Abstract

Two series of experiments were performed to determine the possible involvement of Ca++ channels in the thermolytic action of ethanol administered at a room temperature of 22 degrees C. In one group of 11 adult female Sprague-Dawley rats, stainless steel guide cannulae were implanted stereotaxically above the lateral cerebral ventricle. Prior to an experiment, a thermistor probe was inserted into the colon so that core temperature could be monitored continuously for up to six hours or until the temperature had returned to a previous baseline level. When the animal's body temperature had stabilized, a dose of 4.0 g/kg in a v/v solution of 20% ethanol was given by intragastric gavage. After the body temperature had declined by about 2.0 degrees C, ordinarily 30 min after ethanol administration, either control CSF or the vehicle plus one of four doses of verapamil (8.3, 25, 50 and 100 micrograms) was infused intracerebroventricularly (ICV) in a volume of 10 microliter. In a second group of 7 unoperated rats, either 4.0 g/kg ethanol or a physiological saline control solution was administered isovolumetrically by intragastric gavage; then, 30 min later, either 3.0 or 10.0 mg/kg verapamil was injected intraperitoneally. At an ambient ...Continue Reading

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Citations

Jan 1, 1992·Psychopharmacology·O Pucilowski
Apr 1, 1988·Pharmacology, Biochemistry, and Behavior·C J Gordon, A G Stead
Mar 1, 1993·Pharmacology, Biochemistry, and Behavior·C S O'ConnorJ C Crabbe
Jan 1, 1990·Progress in Neuro-psychopharmacology & Biological Psychiatry·A H Rezvani, D S Janowsky
Jun 14, 2002·Pharmacology, Biochemistry, and Behavior·Amir H Rezvani, Edward D Levin
Sep 24, 2010·Alcoholism, Clinical and Experimental Research·Nicole L Schramm-SapytaCynthia M Kuhn
Sep 24, 2004·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·Amir H Rezvani, Edward D Levin
Jun 1, 1991·The Journal of Pharmacy and Pharmacology·O PucilowskiD S Janowsky
Nov 1, 1989·The Journal of Surgical Research·M KawakamiA H Rezvani

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